{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:21:11Z","timestamp":1791559271746,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Ischemia\u2010reperfusion injury (\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    ) occurs when blood supply returns to tissue after interruption, which is associated with life\u2010threatening inflammatory response. Tranilast is a widely used antiallergic agent in the treatment against bronchial asthma and keloid. To study the function of tranilast, we used\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    in rat models. The brain tissues of\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    rats with or without tranilast treatment were collected. Neuronal apoptosis in the brain was detected by terminal deoxynucleotidyl transferase nick end labeling assay, and proinflammatory cytokine levels were measured by quantitative real\u2010time polymerase chain reaction and enzyme\u2010linked immunosorbent assay. The expression levels of nuclear factor\u2010kappa B (\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB), inhibitor of \u03baB (I\u03baB) and peroxisome proliferator\u2010activated receptors (\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    s) were detected by Western blot. The results showed that tranilast treatment reduced neuronal apoptosis in the brain of\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    rats. Tranilast enhanced the short\u2010term memory and long\u2010term memory to novel object recognition paradigm. Tranilast treatment decreased the messenger RNA (\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    ) and protein levels of multiple proinflammatory cytokines, and affected\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB and inhibitor of kappa B protein expressions. Tranilast promoted the expressions of\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    \u2010\u03b1 and\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    \u2010\u03b3. Our findings demonstrate that tranilast treatment could attenuate cerebral\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    by regulating the inflammatory cytokine production and\n                    <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\n                    expression. Tranilast is a potential drug for\n                    <jats:styled-content style=\"fixed-case\">IRI<\/jats:styled-content>\n                    treatment in the clinic.\n                  <\/jats:p>","DOI":"10.1111\/cts.12606","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T10:14:46Z","timestamp":1544436886000},"page":"196-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tranilast Treatment Attenuates Cerebral Ischemia\u2010Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by\n                    <scp>NF<\/scp>\n                    \u2010\u03baB and\n                    <scp>PPAR<\/scp>\n                    s"],"prefix":"10.1111","volume":"12","author":[{"given":"Yue","family":"Zhuo","sequence":"first","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Affiliated Hospital of Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-018-1664-3"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.04.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00004.2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6127"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6652"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.88"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0424"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.05.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.049"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00668-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.11.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01902148.2016.1207727"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770900903089998"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00561.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.620872"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.49"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2016.59.4.334"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.06.019"},{"key":"e_1_2_10_21_1","first-page":"2253","article-title":"BMMSCs protect against liver ischemia\/reperfusion injury via HO1 mediated autophagy","volume":"18","author":"Wang X.","year":"2018","journal-title":"Mol. 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