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Blood plasma samples were analyzed for metabolite content using liquid chromatography mass spectrometry. Consolidation of positive and negative ion mode metabolomics data with fold change (&gt;2 or &lt;0.5) and variable importance of projection scores\u00a0\u22651 revealed statistically significant metabolites comparing samples from women with and without <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>. Metabolite profiles in patients with <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> differed from the comparison group in energy, lipid and amino acid metabolites reflecting heightened oxidative stress, inflammation, and tryptophan degradation in patients with <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>. Study results may contribute to further identification of unique metabolomic profiles enhancing understanding of the pathophysiology of <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> and for the development of effective therapeutic options.<\/jats:p>","DOI":"10.1111\/cts.12679","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:34:28Z","timestamp":1565778868000},"page":"67-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Metabolomic Differentials in Women With and Without Fibromyalgia"],"prefix":"10.1111","volume":"13","author":[{"given":"Victoria","family":"Menzies","sequence":"first","affiliation":[{"name":"College of Nursing University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Starkweather","sequence":"additional","affiliation":[{"name":"University of Connecticut School of 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