{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:43:56Z","timestamp":1771659836036,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>This prospective cohort study evaluated the association between the renin angiotensin aldosterone system genotypes and response to spironolactone in 155 Egyptian patients with heart failure with reduced ejection fraction (<jats:styled-content style=\"fixed-case\">HFrEF<\/jats:styled-content>). Genotype frequencies for <jats:italic><jats:styled-content style=\"fixed-case\">AGT<\/jats:styled-content><\/jats:italic> rs699 were: <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u00a0=\u00a016%, <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u00a0=\u00a048%, and <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\u00a0=\u00a036%. Frequencies for <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>11B2<\/jats:italic> rs1799998 were: <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\u00a0=\u00a033%, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>\u00a0=\u00a050%, and <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u00a0=\u00a017%. After 6\u00a0months of spironolactone treatment, change in the left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) differed by <jats:italic><jats:styled-content style=\"fixed-case\">AGT<\/jats:styled-content><\/jats:italic> rs699 (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>, 14.6%; <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>, 7.9%; <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, 2.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a02.1E\u201026), and <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>11B2<\/jats:italic> rs1799998 (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, 9.1%; <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>, 8.7%; <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>, 1.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006) genotypes. Multivariate linear regression showed that the <jats:italic><jats:styled-content style=\"fixed-case\">AGT<\/jats:styled-content><\/jats:italic> rs699 and <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>11B2<\/jats:italic> rs1799998 polymorphisms plus baseline serum potassium explained 71% of variability in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> improvement (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), 63% of variability in serum potassium increase (<jats:italic>P<\/jats:italic>\u00a0=\u00a02.25E\u201008), and 39% of the variability in improvement in quality of life (<jats:italic>P<\/jats:italic>\u00a0=\u00a02.3E\u201004) with spironolactone therapy. These data suggest that <jats:italic><jats:styled-content style=\"fixed-case\">AGT<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>11B2<\/jats:italic> genotypes as well as baseline serum K are predictors of spironolactone response in <jats:styled-content style=\"fixed-case\">HFrEF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cts.12702","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T14:26:53Z","timestamp":1569594413000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure"],"prefix":"10.1111","volume":"13","author":[{"given":"Neven M.","family":"Sarhan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy 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