{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:18:00Z","timestamp":1792811880014,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special interest in the Na\n                    <jats:sub>v<\/jats:sub>\n                    1.7 subtype, which is expressed predominantly in nociceptive and sympathetic neurons. The aim was to demonstrate analgesic properties of a potent selective Na\n                    <jats:sub>v<\/jats:sub>\n                    1.7 sodium channel blocker, PF\u201005089771, alone and concomitantly with pregabalin in healthy subjects using a battery of human evoked pain models. This was a double\u2010blind, double\u2010dummy, randomized, placebo\u2010controlled, five\u2010period cross\u2010over study with PF\u201005089771 alone and PF\u201005089771 concomitantly with pregabalin as treatment arms with pregabalin, ibuprofen, and placebo as control arms (NCT02349607). A battery of human evoked pain models was used to investigate analgesic properties of PF\u201005089771. Twenty\u2010five subjects were enrolled in the study of which 23 subjects completed all five periods. PF\u201005089771 alone did not differ from placebo on the primary pain end points. The same holds when comparing PF\u201005089771 concomitantly with pregabalin and pregabalin alone. Pregabalin showed significant effects relative to placebo on thermal pain on the normal skin and UVB skin (least squares means with 90% confidence interval: 0.63 (0.32\u20130.93) and 0.53 (0.11\u20130.96)), pressure stimulation (1.10 (1.04\u20131.18)), and cold pressor (1.22 (1.14\u20131.32)). Ibuprofen demonstrated significant effects on thermal pain UVB skin (1.26 (0.82\u20131.70)) and pressure stimulation assessment (1.08 (1.01\u20131.15)), consistent with historical results. This study did not demonstrate analgesic properties of PF\u201005089771 alone or concomitantly with pregabalin in a battery of pain models.\n                  <\/jats:p>","DOI":"10.1111\/cts.12712","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T06:24:29Z","timestamp":1571811869000},"page":"318-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Lack of Detection of the Analgesic Properties of PF\u201005089771, a Selective Na\n                    <sub>v<\/sub>\n                    1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects"],"prefix":"10.1111","volume":"13","author":[{"given":"Pieter","family":"Siebenga","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"van Amerongen","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Hay","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoibhinn","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Neuroscience and Pain Research Unit Pfizer WRD Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donal","family":"Gorman","sequence":"additional","affiliation":[{"name":"Neuroscience and Pain Research Unit Pfizer WRD Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Butt","sequence":"additional","affiliation":[{"name":"Neuroscience and Pain Research Unit Pfizer WRD Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Groeneveld","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research Leiden The Netherlands"},{"name":"Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.01.444"},{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00074-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054865028"},{"key":"e_1_2_12_4_1","first-page":"682","article-title":"Future potential and status of selective sodium channel blockers for the treatment of pain","volume":"12","author":"Priest B.T.","year":"2009","journal-title":"Curr. 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