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Real\u2010world psoriasis data were used to develop a pharmacokinetic\/pharmacodynamic (PK\/PD) model for the first\u2010line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data\u00a0were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti\u2010drug antibody measurements on 797 serum samples, 1,590 measurements of Psoriasis Area Severity Index (PASI)). Ustekinumab PKs were described with a linear one\u2010compartment model. A maximum effect (E<jats:sub>max<\/jats:sub>) model inhibited progression of psoriatic skin lesions in the turnover PD mechanism describing PASI evolution while on treatment. 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