{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:30:41Z","timestamp":1787697041305,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>This exploratory study aimed to develop a risk prediction model of vancomycin\u2010associated nephrotoxicity (VANT) in elderly patients. Clinical information of elderly patients who received vancomycin therapy from January 2016 to June 2018 was retrieved. A total of 255 patients were included in this study. Univariate analysis and multivariable logistic regression analysis revealed that vancomycin trough concentration \u2265\u00a020\u00a0mg\/L (odds ratio (OR)\u00a0=\u00a03.009; 95% confidence interval (CI) 1.345\u20136.732), surgery (OR\u00a0=\u00a03.357; 95% CI 1.309\u20138.605), the Charlson Comorbidities Index \u2265\u00a04 points (OR\u00a0=\u00a02.604; 95% CI 1.172\u20135.787), concomitant\u00a0use of cardiotonic\u00a0drug (OR\u00a0=\u00a03.283; 95% CI 1.340\u20138.042), plasma volume expander (OR\u00a0=\u00a03.459; 95% CI 1.428\u20138.382), and piperacillin\/tazobactam (OR\u00a0=\u00a02.547; 95% CI 1.680\u20136.007) were risk factors for VANT in elderly patients. Furthermore, a VANT risk prediction model was developed, which had good discriminative power and was well\u2010calibrated.<\/jats:p>","DOI":"10.1111\/cts.12731","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:12:59Z","timestamp":1575281579000},"page":"491-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Development and Validation of a Risk Prediction Model of Vancomycin\u2010Associated Nephrotoxicity in Elderly Patients: A Pilot Study"],"prefix":"10.1111","volume":"13","author":[{"given":"Chen","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"e_1_2_10_2_1","first-page":"734","article-title":"Systematic review and meta\u2010analysis of vancomycin\u2010induced nephrotoxicity associated with dosing schedules that maintain troughs between 15 and 20 milligrams per liter","volume":"2","author":"Hal S.J.","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13039"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002743"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.10.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381783"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.4.679"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.12.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/600884"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.08.019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13594"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0634-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006023"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.06.025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/FTD.0000000000000459","article-title":"Relationship between initial vancomycin trough levels and early\u2010onset vancomycin\u2010associated nephrotoxicity in critically ill patients","volume":"1","author":"Chuma M.","year":"2018","journal-title":"Ther. Drug Monit."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000514"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.06.012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066618768749"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-013-0163-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1504300507"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.946"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.05.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002769"},{"key":"e_1_2_10_25_1","first-page":"666","article-title":"Systematic review and meta\u2010analysis of acute kidney injury associated with concomitant vancomycin and piperacillin\/tazobactam","volume":"5","author":"Hammond D.A.","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00525-15"},{"key":"e_1_2_10_27_1","first-page":"349","article-title":"Efficacy of vancomycin on gram\u2010positive bacterial infection in elderly critical patients and risk factors associated with nephrotoxicity","volume":"8","author":"Huang M.","year":"2018","journal-title":"Arch. Iran Med."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.350"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw254"},{"key":"e_1_2_10_31_1","first-page":"236","article-title":"Is the Charlson Comorbidity Index a prognostic indicator for toxicity and mortality in elderly patients with locally advanced rectal cancer?","volume":"5","author":"Kostek O.","year":"2019","journal-title":"Arch. Iran Med."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111254"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix675"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12731","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:40:31Z","timestamp":1694040031000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/cts.12731"],"URL":"https:\/\/doi.org\/10.1111\/cts.12731","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"2019-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}