{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:30Z","timestamp":1790873790149,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773820"],"award-info":[{"award-number":["81773820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    This study aimed at exploring the concentration\u2010effect relationship of adalimumab and early adalimumab and anti\u2010adalimumab antibody (AAA) levels in predicting primary nonresponse in a real\u2010world pilot cohort of patients with ankylosing spondylitis. Thirty\u2010one patients were included. The Ankylosing Spondylitis Disease Activity Score improved with increasing adalimumab trough level at week 12 and reached a major improvement with levels between 8 and 12\u00a0\u03bcg\/mL. Moreover, weeks 4 and 2 adalimumab levels below 4.28 and 3.37\u00a0\u03bcg\/mL were predictive of primary nonresponse (area under the curve (AUC)\u00a0=\u00a00.89, 0.88;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.0003,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.034, respectively). Week 4 AAA signal\u2010to\u2010noise levels were significantly higher among primary nonresponders, and the cutoff for primary nonresponse prediction was above 5.31 (AUC\u00a0=\u00a00.81;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.004). Adalimumab trough levels in a range of 8\u201312\u00a0\u03bcg\/mL are optimum to reach major improvement, and lower adalimumab with higher AAA levels at the early stage (week 4) predict primary nonresponse by supporting proactive monitoring to optimize adalimumab therapy.\n                  <\/jats:p>","DOI":"10.1111\/cts.12738","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T09:08:15Z","timestamp":1579597695000},"page":"547-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Early Adalimumab and Anti\u2010Adalimumab Antibody Levels for Prediction of Primary Nonresponse in Ankylosing Spondylitis Patients"],"prefix":"10.1111","volume":"13","author":[{"given":"Xiaoliang","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology the First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute for Interdisciplinary Drug Research and Translational Sciences College of Pharmaceutical Sciences Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology the First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute for Interdisciplinary Drug Research and Translational Sciences College of Pharmaceutical Sciences Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology the First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology the First Affiliated Hospital of Soochow University Suzhou China"},{"name":"Institute for Interdisciplinary Drug 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