{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:43:46Z","timestamp":1787240626251,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    The essential oil from the leaves of\n                    <jats:italic>Zhumeria majdae<\/jats:italic>\n                    Rech. (ZMEO) has been shown to have several beneficial effects in the clinic. In this work we examined the anticonvulsant activities of ZMEO in an experimental mouse model of seizure and aimed to identify any possible underlying mechanisms. ZMEO (5, 10, 20, and 40\u00a0mg\/kg intraperitoneally (i.p.)) or diazepam, as the reference anticonvulsant drug (25, 50 and 100\u00a0\u00b5g\/kg i.p.), were administered 60\u00a0minutes prior to pentylenetetrazol (PTZ) injection (intravenously (i.v.) or i.p.) and changes in threshold, latency, and frequency of clonic seizure were examined. The PTZ i.p.\u2010induced model of seizure was also applied for examining the protective effects of ZMEO pretreatment against PTZ\u2010induced mortality. In some studies, the anticonvulsant effect of the combination of diazepam and ZMEO was also studied. The protective effects of ZMEO against hindlimb tonic extensions (HLTEs) were also examined by maximal electroshock (MES) seizure testing. The \u03b3\u2010aminobutyric acid (GABA)ergic mechanism and nitric oxide (NO) pathway involvement in anticonvulsant activity of ZMEO were assessed by pretreating animals with flumazenil,\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>\u03c9<\/jats:sup>\n                    \u2010nitro\u2010L\u2010arginine methyl ester (L\u2010NAME), aminoguanidine, and L\u2010arginine in a PTZ\u2010induced model of seizure. Administration of 20\u00a0mg\/kg ZMEO significantly increased chronic seizure threshold and latency while reducing frequency of convulsions and mortality in the PTZ\u2010induced model. In the doses studied, ZMEO could not protect mice from HLTE and mortality induced by MES. Pretreatment with L\u2010arginine and diazepam potentiated the anticonvulsant effects of ZMEO, whereas pretreatment with L\u2010NAME, aminoguanidine, and flumazenil reversed anticonvulsant activity. The anticonvulsant activity of ZMEO may be mediated in part through a GABAergic mechanism and the NO signaling pathway.\n                  <\/jats:p>","DOI":"10.1111\/cts.12767","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T09:32:06Z","timestamp":1580981526000},"page":"785-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anticonvulsant Activity of Essential Oil From Leaves of\n                    <i>Zhumeria majdae<\/i>\n                    (Rech.) in Mice: The Role of GABA\n                    <sub>A<\/sub>\n                    Neurotransmission and the Nitric Oxide Pathway"],"prefix":"10.1111","volume":"13","author":[{"given":"Helia","family":"Aghamiri","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy and Pharmaceutical Sciences Tehran Medical Sciences Islamic Azad University Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Shafaroodi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinous","family":"Asgarpanah","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical Sciences Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-107"},{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Epilepsy: Fact Sheet No 999. 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