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Data from a prospective, multicenter study were used. Modeling and simulations were conducted using Nonlinear Mixed\u2010Effects Modeling (NONMEM) and R software. A total of 281 white patients were included to develop the Pop\u2010PK model. The final model developed for apparent oral clearance (CL\/F) included weight, estimated glomerular filtration rate (eGFR), and diabetes, which partly explained its interindividual variability. The mean CL\/F value estimated was 7.6 L\/h (1.7\u201322.6 L\/h). Simulations revealed that an important decrease in CL\/F (&gt;\u00a025%) is obtained with the combination of the factors retained in the final model. Considering these factors, a more individualized approach of candesartan dosing should be investigated in patients with HF.<\/jats:p>","DOI":"10.1111\/cts.12842","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T17:52:17Z","timestamp":1595526737000},"page":"194-203","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure"],"prefix":"10.1111","volume":"14","author":[{"given":"Imad","family":"Kassem","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Montreal Heart Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Sanche","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montreal Quebec 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