{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:58:57Z","timestamp":1773295137746,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Upper limb lymphedema is one of the most common complications after breast cancer surgery and radiotherapy. Despite various physical therapy and surgical options available, the impaired lymph fluid drainage may be progressive due to lymphatic vascular insufficiency making treatment more difficulty. Stem cell therapy provides a promising alternative in the treatment of various chronic diseases. The wide applicability of cell therapy has been reviewed throughout literature. This review provides an overview of recent progress in the therapeutic effect of adult stem cells for primary and secondary lymphedema after breast surgery in preclinical studies and clinical cases. We start with a brief introduction about the pathophysiological mechanisms of postmastectomy lymphedema. Regarding existing treatments, we systematically summarize the benefits and limitations of recent progress. Because of their multidirectional differentiation potential and growth factor secretion, stem cell therapy shows promising results in the management of light to severe lymphedema. Increasing evidences have demonstrated a noticeable reduction in postmastectomy lymphedema and increased lymph\u2010angiogenesis after specific stem cell therapy. Current data suggests that stem cell therapy in lymphedema treatment provides reversal of pathological reorganization associated with lymphedema progression. Finally, we propose potential strategies for overcoming the challenges in the development of multipotent progenitor cells for the treatment and prevention of lymphedema in clinical practice.<\/jats:p>","DOI":"10.1111\/cts.12864","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T13:53:05Z","timestamp":1597585985000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic Potential of Mesenchymal Stem Cells for Postmastectomy Lymphedema: A Literature Review"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-8545","authenticated-orcid":false,"given":"Kuo","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-6011","authenticated-orcid":false,"given":"Mikhail Y.","family":"Sinelnikov","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine I.M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor V.","family":"Reshetov","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Timashev","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine I.M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanting","family":"Gu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-0652","authenticated-orcid":false,"given":"Lan","family":"Mu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-7069","authenticated-orcid":false,"given":"Pengwei","family":"Lu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.05.015"},{"key":"e_1_2_8_2_1","article-title":"Review of preclinical and clinical studies of using cell\u2010based therapy for secondary lymphedema","author":"Chen C.E.","year":"2020","journal-title":"J. Surg. Oncol."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000246516.64780.61"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-52423-8_42"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01116.2012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272088"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7252-4"},{"key":"e_1_2_8_8_1","first-page":"170","article-title":"The diagnosis and treatment of peripheral lymphedema: 2016 consensus document of the international society of lymphology","volume":"49","author":"Executive Committee","year":"2016","journal-title":"Lymphology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041126"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a4d626"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35955-9.00036-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-14493-1_2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15238"},{"key":"e_1_2_8_14_1","first-page":"633","article-title":"Primary cutaneous monomelic B\u2010cell lymphoma","volume":"124","author":"Marquart\u2010Elbaz C.","year":"1997","journal-title":"Ann. Dermatol. Vener."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004116510"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2011.594791"},{"key":"e_1_2_8_17_1","first-page":"541","article-title":"Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)\u20102013","volume":"32","author":"Lee B.B.","year":"2013","journal-title":"Int. Angiol."},{"key":"e_1_2_8_18_1","first-page":"4875","article-title":"Current treatments for breast cancer\u2010related lymphoedema: a systematic review","volume":"17","author":"Li L.","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008380"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2009.0002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010171"},{"key":"e_1_2_8_22_1","first-page":"247","article-title":"Current status and trends of breast reconstruction with simultaneously treatment and prevention of upper limb lymphedema","volume":"34","author":"Lan M.","year":"2018","journal-title":"China J. Plast. Surg."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004673"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.01.007"},{"key":"e_1_2_8_25_1","first-page":"537","article-title":"Experimental evidence of direct communications between lymph nodes and veins","volume":"113","author":"Pressman J.J.","year":"1961","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_8_26_1","first-page":"984","article-title":"Further observations related to direct communications between lymph nodes and veins","volume":"119","author":"Pressman J.L.","year":"1964","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24413"},{"key":"e_1_2_8_28_1","first-page":"455","article-title":"Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues","volume":"31","author":"Anderson N.D.","year":"1976","journal-title":"Immunology"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24170"},{"key":"e_1_2_8_30_1","unstructured":"National Institutes of Health (NIH).Stem cells: scientific progress and future research directions(August 6 2001) <http:\/\/www.nih.gov\/news\/stemcell\/scireport.htm>."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0737"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.5.569"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.211"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704421104"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39477"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.04.017"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26121"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0093"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.08.004"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-018-0127-x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000126"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.384"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000995"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000737"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12667"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2015.10.001"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2015.1122872"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.04.002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17-0037"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0357"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2015.09.001"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.15.24"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.02.051"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000084"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/cell.2016.0038"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829ace13"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0390"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2014.964726"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0027"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/cell.2015.0003"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003110"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000688"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0015"},{"key":"e_1_2_8_65_1","first-page":"1109","article-title":"Commonly used mesenchymal stem cell markers and tracking labels: limitations and challenges","volume":"28","author":"Lin C.S.","year":"2013","journal-title":"Histol. Histopathol."},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-018-0122-7"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000064"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcts.12864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T06:08:29Z","timestamp":1693634909000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,30]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cts.12864"],"URL":"https:\/\/doi.org\/10.1111\/cts.12864","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,30]]},"assertion":[{"value":"2020-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}