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Combined QTc findings from electrocardiograms taken during oral and i.v. pharmacokinetic\u2010pharmacodynamic studies of AZ suggest that clinically meaningful QTc prolongation is unlikely. Findings from several observational studies were heterogeneous and not as consistent as results from at least two large randomized controlled trials (RCTs). The QTc findings presented and observational data from studies with large numbers of events are not consistent with either a proarrhythmic action of AZ or an increase in frequency of CV deaths. Well\u2010powered RCTs do not suggest a presence of increased risk of CV or sudden cardiac death after short\u2010term or protracted periods of AZ usage, even in patients at higher risk from pre\u2010existing coronary disease.<\/jats:p>","DOI":"10.1111\/cts.12867","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T17:23:10Z","timestamp":1600708990000},"page":"106-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Weight of Evidence From Electrophysiology, Observational, and Cardiovascular End Point Studies Demonstrates the Safety of Azithromycin"],"prefix":"10.1111","volume":"14","author":[{"given":"Jack","family":"Cook","sequence":"first","affiliation":[{"name":"Pfizer Global Research and Development  Groton Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton L.","family":"Pressler","sequence":"additional","affiliation":[{"name":"Pfizer Global Research and Development  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Damle","sequence":"additional","affiliation":[{"name":"Pfizer Global Research and Development  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demissie","family":"Alemayehu","sequence":"additional","affiliation":[{"name":"Pfizer Global Research and Development  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Knirsch","sequence":"additional","affiliation":[{"name":"Pfizer Global Research and Development  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00807-7"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1715474"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003833"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1207269"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2016.03.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008662"},{"key":"e_1_2_10_7_1","article-title":"Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID\u201019)","author":"Mercuro N.J.","journal-title":"JAMA Cardiol."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012410"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8630"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1857"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2518-2524.2002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/508175"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01023-06"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.929"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706900"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1459"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043526"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000056032.56396.89"},{"key":"e_1_2_10_19_1","unstructured":"Recovery Study. <https:\/\/www.recoverytrial.net\/>. 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