{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:26:04Z","timestamp":1783617964112,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>High\u2010dose (HD) methotrexate (MTX) is a critical component of treatment for hematologic malignancies in children and young adults. Therapeutic drug monitoring is necessary due to substantial interindividual variation in MTX clearance. Common function\u2010altering polymorphisms in <jats:italic>SLCO1B1<\/jats:italic> (encodes OATP1B1, which transports MTX) may contribute to clearance variability. We performed pharmacokinetic modeling using data for 106 children and young adults treated with HD MTX for hematologic malignancies; of 396 total courses of HD MTX, 360 consisted of 5 g\/m<jats:sup>2<\/jats:sup> over 24 hours. We evaluated the contribution of clinical covariates and <jats:italic>SLCO1B1<\/jats:italic> genotype (388A&gt;G and 521T&gt;C) to MTX clearance variability. Of the clinical covariates studied, patient weight improved the pharmacokinetic model most significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). The addition of the <jats:italic>SLCO1B1<\/jats:italic> variants individually further improved the model (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05 for each). An interaction between these variants was suggested when both were included (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.017). <jats:italic>SLCO1B1<\/jats:italic> genotype should be considered in efforts to personalize HD MTX dosing.<\/jats:p>","DOI":"10.1111\/cts.12879","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:49:38Z","timestamp":1600822178000},"page":"343-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Effect of <i>SLCO1B1<\/i> Polymorphisms on High\u2010Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma"],"prefix":"10.1111","volume":"14","author":[{"given":"Rachael R.","family":"Schulte","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Utreja","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology\/Oncology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara L.","family":"Van Driest","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of General Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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