{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:51:14Z","timestamp":1781110274053,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000395","name":"Royal College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Adenosine boasts promising preclinical and clinical data supporting a vital role in modulating vascular homeostasis. Its widespread use as a diagnostic and therapeutic agent have been limited by its short half\u2010life and complex biology, though adenosine\u2010modulators have shown promise in improving vascular healing. Moreover, circulating adenosine has shown promise in predicting cardiovascular (CV) events. We sought to delineate whether circulating plasma adenosine levels predict CV events in patients undergoing invasive assessment for coronary artery disease. Patients undergoing invasive angiography had clinical data prospectively recorded in the Cardiovascular and Percutaneous ClInical TriALs (CAPITAL) revascularization registry and blood samples collected in the CAPITAL Biobank from which adenosine levels were quantified. Tertile\u2010based analysis was used to assess prediction of major adverse cardiovascular events (MACE; composite of death, myocardial infarction, unplanned revascularization, and cerebrovascular accident). Secondary analyses included MACE subgroups, clinical subgroups and adenosine levels. There were 1,815 patients undergoing angiography who had blood collected with adenosine quantified in 1,323. Of those quantified, 51.0% were revascularized and 7.3% experienced MACE in 12\u00a0months of follow\u2010up. Tertile\u2010based analysis failed to demonstrate any stratification of MACE rates (log rank, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.83), when comparing low\u2010to\u2010middle (hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.68\u20131.78, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.70) or low\u2010to\u2010high adenosine tertiles (HR 0.95, 95% CI 0.56\u20131.57, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.84). In adjusted analysis, adenosine similarly failed to predict MACE. Finally, adenosine did not predict outcomes in patients with acute coronary syndrome nor in those revascularized or treated medically. Plasma adenosine levels do not predict subsequent CV outcomes or aid in patient risk stratification.<\/jats:p>","DOI":"10.1111\/cts.12886","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:27:45Z","timestamp":1606948065000},"page":"354-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Performance of Plasma Adenosine as a Biomarker for Predicting Cardiovascular Risk"],"prefix":"10.1111","volume":"14","author":[{"given":"Trevor","family":"Simard","sequence":"first","affiliation":[{"name":"CAPITAL Research Group Division of Cardiology University of Ottawa Heart Institute  Ottawa Ontario Canada"},{"name":"Department of Cellular and Molecular Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"Division of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Jung","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group Division of Cardiology University of Ottawa Heart Institute  Ottawa Ontario Canada"},{"name":"Department of Cellular and Molecular Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Di Santo","sequence":"additional","affiliation":[{"name":"CAPITAL Research Group Division of Cardiology University of Ottawa Heart Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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