{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:00:50Z","timestamp":1785236450756,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Extranodal natural killer\/T\u2010cell lymphoma, nasal type (ENKL) is a rare peripheral T\u2010cell lymphoma that predominantly occurs in Asian and South American populations. The treatment of ENKL has been a challenge for a long time. This study was conducted to compare the clinical efficacy and safety of cisplatin, dexamethasone, gemcitabine, and pegaspargase (DDGP) and methotrexate, dexamethasone, ifosfamide, L\u2010asparaginase, and etoposide (SMILE) regimens for relapsed\/refractory ENKL and explore the prognostic factors. From October 2014 to July 2019, 54 patients with relapsed\/refractory ENKL who received DDGP or SMILE chemotherapy were retrospectively assessed in this study. Thirty\u2010one patients received DDGP chemotherapy and 23 patients received SMILE chemotherapy. A higher complete response rate was observed in patients treated with DDGP regimen (61.3% vs. 30.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025). The DDGP group (95% confidence interval (CI) of 5\u2010year progression\u2010free survival (PFS): 24.6\u201366.2%; 95% CI of 5\u2010year overall survival (OS): 8.5\u201391.7%) was also significantly associated with longer 5\u2010year PFS and 5\u2010year OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008 for 5\u2010year PFS, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023 for 5\u2010year OS). More serious leucopenia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021), neutropenia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.041), and allergy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.040) were observed in the SMILE group. Post\u2010treatment Epstein\u2013Barr virus (EBV)\u2010DNA status (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 for PFS, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018 for OS) was identified as a significant prognostic factor for PFS and OS in multivariate analysis. The present research suggested that compared with SMILE chemotherapy, DDGP chemotherapy can significantly improve the response and survival of relapsed\/refractory ENKL with better tolerance. Post\u2010treatment EBV\u2010DNA status was identified as a significant prognostic factor for PFS and OS in relapsed\/refractory ENKL.<\/jats:p>","DOI":"10.1111\/cts.12893","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T21:11:50Z","timestamp":1602537110000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["DDGP vs. SMILE in Relapsed\/Refractory Extranodal Natural Killer\/T\u2010cell Lymphoma, Nasal Type: A Retrospective Study of 54 Patients"],"prefix":"10.1111","volume":"14","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"},{"name":"Lymphoma Diagnosis and Treatment Center of Henan Province  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00386"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1961058"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2776-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.11.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-018-0430-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6287"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-791418"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127811"},{"key":"e_1_2_10_9_1","unstructured":"National Comprehensive Cancer Network (NCCN).Clinical Practice Guidelines in Oncology. T\u2010Cell Lymphomas Version 1. 2020. <https:\/\/www.nccn.org\/profe\u200bssion\u200bals\/physi\u200bcian\u2010gls\/f_guide\u200blines.asp>."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2136-7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00533-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431460"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0720-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0153"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S191929"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11135"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10124"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.051"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534347"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.10.011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2325"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8643"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435024"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3327"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.212"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12540"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012534"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12893","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T06:05:40Z","timestamp":1693634740000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cts.12893"],"URL":"https:\/\/doi.org\/10.1111\/cts.12893","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"2020-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}