{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:41Z","timestamp":1772160101711,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    Recommendations regarding ibuprofen use in relation to coronavirus disease 2019 (COVID\u201019) have been conflicting. We examined the risk of severe COVID\u201019 between ibuprofen\u2010prescribed and non\u2010ibuprofen patients with COVID\u201019 in a nationwide register\u2010based study of patients with COVID\u201019 in Denmark between the end of February 2020 and May 16, 2020. Patients with heart failure (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0208), &lt;\u00a030\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0575), and prescribed other nonsteroidal anti\u2010inflammatory drugs (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a057) were excluded. Patients with ibuprofen prescription claims between January 1, 2020, and before COVID\u201019 diagnosis or April 30, 2020 (last available prescription) were compared with patients without ibuprofen prescription claims. Outcome was a 30\u2010day composite of severe COVID\u201019 diagnosis with acute respiratory syndrome, intensive care unit admission, or death. Absolute risks and average risk ratios comparing outcome for ibuprofen vs. non\u2010ibuprofen patients standardized to the age, sex, and comorbidity distribution of all patients were derived from multivariable Cox regression. Among 4,002 patients, 264 (6.6%) had ibuprofen prescription claims before COVID\u201019. Age, sex, and comorbidities were comparable between the two study groups. Standardized absolute risks of the composite outcome for ibuprofen\u2010prescribed vs. non\u2010ibuprofen patients were 16.3% (95% confidence interval (CI) 12.1\u201320.6) vs. 17.0% (95% CI 16.0\u201318.1),\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.74. The standardized average risk ratio for ibuprofen\u2010prescribed vs. non\u2010ibuprofen patients was 0.96 (95% CI 0.72\u20131.23). Standardized absolute risks of the composite outcome for patients with ibuprofen prescription claims &gt;\u00a014\u00a0days before COVID\u201019 vs. \u2264\u00a014\u00a0days of COVID\u201019 were 17.1% (95% CI 12.3\u201322.0) vs. 14.3% (95% CI 7.1\u201323.1). In conclusion, in this nationwide study, there was no significant association between ibuprofen prescription claims and severe COVID\u201019.\n                  <\/jats:p>","DOI":"10.1111\/cts.12904","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T14:44:40Z","timestamp":1600958680000},"page":"1103-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association Between Prescribed Ibuprofen and Severe COVID\u201019 Infection: A Nationwide Register\u2010Based Cohort Study"],"prefix":"10.1111","volume":"13","author":[{"given":"Kristian","family":"Kragholm","sequence":"first","affiliation":[{"name":"Unit of Clinical Biostatistics and Epidemiology Aalborg University Hospital Aalborg Denmark"},{"name":"Departments of Cardiology North Denmark Regional Hospital and Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Gerds","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Copenhagen University Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel Porsborg","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Nordsjaellands Hospital Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Phelps","sequence":"additional","affiliation":[{"name":"The Danish Heart Foundation Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawad H.","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauge","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper N.","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Nordsjaellands Hospital Hiller\u00f8d Denmark"},{"name":"The Danish Heart Foundation Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannik","family":"Pallisgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"The Danish Heart Foundation Copenhagen Denmark"},{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev\u2010Gentofte Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Nordsjaellands Hospital Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"crossref","first-page":"m1966","DOI":"10.1136\/bmj.m1966","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study","volume":"22","author":"Petrilli C.M.","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb2005114"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"2000285","DOI":"10.2807\/1560-7917.ES.2020.25.11.2000285","article-title":"Rapidly increasing cumulative incidence of coronavirus disease (COVID\u201019) in the European Union\/European Economic Area and the United Kingdom, 1 January to 15 March 2020","volume":"25","author":"Kinross P.","year":"2020","journal-title":"Euro Surveill."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.1447"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.12734"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2020.1023"},{"key":"e_1_2_10_11_1","unstructured":"The Danish Health Data Authority.Management of COVID\u201019 in healthcare cost and financing<https:\/\/sundhedsdatastyrelsen.dk\/\u2010\/media\/sds\/filer\/finansiering\u2010og\u2010afregning\/gruppering\/noegler\/2020\/bilag\u20102\u2010_\u2010haandtering\u2010af\u2010covid_19\u2010i\u2010drg.pdf>. Accessed on August 31 2020."},{"key":"e_1_2_10_12_1","first-page":"104","article-title":"Short\u2010term mortality risk of serum potassium levels in hypertension: a retrospective analysis of nationwide registry data","volume":"38","author":"Krogager M.L.","year":"2017","journal-title":"Eur. Heart J."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7450"},{"key":"e_1_2_10_14_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"m1086","DOI":"10.1136\/bmj.m1086","article-title":"Covid\u201019: ibuprofen should not be used for managing symptoms, say doctors and scientists","volume":"17","author":"Day M.","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_10_16_1","article-title":"The COVID\u201019 ibuprofen controversy: a systematic review of NSAIDs in adult acute lower respiratory tract infections","author":"Vaja R.","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1259.e5","DOI":"10.1016\/j.cmi.2020.06.003","article-title":"Ibuprofen use and clinical outcomes in COVID\u201019 patients","volume":"26","author":"Rinott E.","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s40264-020-00953-0","article-title":"Does Ibuprofen Worsen COVID\u201019?","volume":"43","author":"Nicholas Moore N.","year":"2020","journal-title":"Drug Saf."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104849"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T05:28:47Z","timestamp":1693805327000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/cts.12904"],"URL":"https:\/\/doi.org\/10.1111\/cts.12904","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-26247\/v1","asserted-by":"object"}]},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"2020-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}