{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:13:23Z","timestamp":1775582003555,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008731","name":"Nakatomi Foundation","doi-asserted-by":"publisher","award":["JP17K17983"],"award-info":[{"award-number":["JP17K17983"]}],"id":[{"id":"10.13039\/100008731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Lisinopril, a highly hydrophilic long\u2010acting angiotensin\u2010converting enzyme inhibitor, is frequently prescribed for the treatment of hypertension and congestive heart failure. Green tea consumption may reduce the risk of cardiovascular outcomes and total mortality, whereas green tea or its catechin components has been reported to decrease plasma concentrations of a hydrophilic \u03b2 blocker, nadolol, in humans. The aim of this study was to evaluate possible effects of green tea extract (GTE) on the lisinopril pharmacokinetics. In an open\u2010label, randomized, single\u2010center, 2\u2010phase crossover study, 10 healthy subjects ingested 200\u00a0mL of an aqueous solution of GTE containing ~\u00a0300\u00a0mg of (\u2013)\u2010epigallocatechin gallate, a major catechin component in green tea, or water (control) when receiving 10\u00a0mg of lisinopril after overnight fasting. The geometric mean ratio (GTE\/control) for maximum plasma concentration and the area under the plasma concentration\u2010time curve of lisinopril were 0.289 (90% confidence interval (CI) 0.226\u20130.352) and 0.337 (90% CI 0.269\u20130.405), respectively. In contrast, there were no significant differences in time to reach maximum lisinopril concentration (6\u00a0hours in both phases) and renal clearance of lisinopril (57.7\u00a0mL\/minute in control vs. 56.9\u00a0mL\/minute in GTE). These results suggest that the extent of intestinal absorption of lisinopril was significantly impaired in the presence of GTE, whereas it had no major effect on the absorption rate and renal excretion of lisinopril. Concomitant use of lisinopril and green tea may decrease oral exposure to lisinopril, and therefore result in reduced therapeutic efficacy.<\/jats:p>","DOI":"10.1111\/cts.12905","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T19:08:15Z","timestamp":1602616095000},"page":"476-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-6897","authenticated-orcid":false,"given":"Shingen","family":"Misaka","sequence":"first","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Yamanashi Hospital Chuo\u2010city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Yamanashi Hospital Chuo\u2010city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Onoue","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Shikama","sequence":"additional","affiliation":[{"name":"Center for Medical Education and Career Development Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenju","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine School of Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"ClinCalc.com.The top 200 drugs in 2020<https:\/\/clincalc.com\/DrugStats\/> (2020). Accessed March 23 2020."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb01991.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015823315983"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13301.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.143339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.06.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9960-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00204-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-12-RG-101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139370"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.036640"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.241"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2436-2"},{"key":"e_1_2_9_14_1","article-title":"Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers","author":"Misaka S.","journal-title":"Br. J. Clin. Pharmacol."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600750416"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03308.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498258809042240"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-004-9004-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf070323f"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00564-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2017.1387515"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.01.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.04.018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.089656"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1301"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00085"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01857634"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12905","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:27:25Z","timestamp":1693607245000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cts.12905"],"URL":"https:\/\/doi.org\/10.1111\/cts.12905","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"assertion":[{"value":"2020-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}