{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:00:24Z","timestamp":1790841624412,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Coronavirus disease 2019 (COVID\u201019) is often associated with interstitial pneumonia. However, there is insufficient knowledge on the presence of autoimmune serological markers in patients with COVID\u201019. We analyzed the presence and role of autoantibodies in patients with COVID\u201019\u2010associated pneumonia. We prospectively studied 33 consecutive patients with COVID\u201019, 31 (94%) of whom had interstitial pneumonia, and 25 age\u2010matched and sex\u2010matched patients with fever and\/or pneumonia with etiologies other than COVID\u201019 as the pathological control group. All patients were tested for the presence of antinuclear antibodies (ANAs), anti\u2010antiphospholipid antibodies, and anti\u2010cytoplasmic neutrophil antibodies (ANCAs). Clinical, biochemical, and radiological parameters were also collected. Fifteen of 33 patients (45%) tested positive for at least one autoantibody, including 11 who tested positive for ANAs (33%), 8 who tested positive for anti\u2010cardiolipin antibodies (immunoglobulin (Ig)G and\/or IgM; 24%), and 3 who tested positive for anti\u2010\u03b22\u2010glycoprotein antibodies (IgG and\/or IgM; 9%). ANCA reactivity was not detected in any patient. Patients that tested positive for auto\u2010antibodies had a significantly more severe prognosis than other patients did: 6 of 15 patients (40%) with auto\u2010antibodies died due to COVID\u201019 complications during hospitalization, whereas only 1 of 18 patients (5.5%) who did not have auto\u2010antibodies died (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.03). Patients with poor prognosis (death due to COVID\u201019 complications) had a significantly higher respiratory rate at admission (23 breaths per minute vs. 17 breaths per minute;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and a higher frequency of auto\u2010antibodies (86% vs. 27%;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). In conclusion, auto\u2010antibodies are frequently detected in patients with COVID\u201019 possibly reflecting a pathogenetic role of immune dysregulation. However, given the small number of patients, the association of auto\u2010antibodies with an unfavorable prognosis requires further multicenter studies.<\/jats:p>","DOI":"10.1111\/cts.12908","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:33:09Z","timestamp":1601368389000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["COVID\u201019 and Immunological Dysregulation: Can Autoantibodies be Useful?"],"prefix":"10.1111","volume":"14","author":[{"given":"Simona","family":"Pascolini","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vannini","sequence":"additional","affiliation":[{"name":"Medicina d'Urgenza e Pronto Soccorso Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Deleonardi","sequence":"additional","affiliation":[{"name":"Metropolitan Laboratory Department of Immunology AUSL Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ciordinik","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Sensoli","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Carletti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Veronesi","sequence":"additional","affiliation":[{"name":"Medicina d'Urgenza e Pronto Soccorso Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ricci","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Pronesti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Grondona","sequence":"additional","affiliation":[{"name":"Metropolitan Laboratory Department of Immunology AUSL Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Metropolitan Laboratory Department of Immunology AUSL Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Zanuso","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Mazzolini","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Lalanne","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Quarneti","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fusconi","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Giostra","sequence":"additional","affiliation":[{"name":"Medicina d'Urgenza e Pronto Soccorso Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Granito","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Muratori","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muratori","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Sciences for the Quality of Life University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"e_1_2_10_1_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) Weekly Epidemiological Update and Weekly Operational Update. <https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/situation\u2010reports> (2020)"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_10_6_1","article-title":"Respiratory support in severely or critically ill ICU patients with COVID\u201019 in Wuhan, China","author":"Hu H.T.","journal-title":"Curr. Med. Sci."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8907"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.04.030"},{"key":"e_1_2_10_9_1","first-page":"113e22","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019) \u2013 China, 2020","volume":"2","author":"The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team","year":"2020","journal-title":"China CDC Weekly"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.10.2000180"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2020007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6913e1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102537"},{"key":"e_1_2_10_15_1","first-page":"1","article-title":"Immune responses in COVID\u201019 and potential vaccines: lessons learned from SARS and MERS epidemic","volume":"38","author":"Prompetchara E.","year":"2020","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16749"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14867"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2007575"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.388"},{"key":"e_1_2_10_22_1","article-title":"Clinical and autoimmune characteristics of severe and critical cases of COVID\u201019","author":"Zhou Y.","journal-title":"Clin. Transl. Sci."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154262"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39755"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0034-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014175"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200111000-00002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3VMR0220-438RR"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1684\/ecn.2019.0439","article-title":"Serum levels of interleukin\u201032 and interleukin\u20106 in granulomatosis with polyangiitis and microscopic polyangiitis: association with clinical and biochemical findings","volume":"30","author":"Krajewska Wojciechowska J.","year":"2019","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.11.010"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.002"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.12908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.12908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:18:26Z","timestamp":1698189506000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.12908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cts.12908"],"URL":"https:\/\/doi.org\/10.1111\/cts.12908","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"assertion":[{"value":"2020-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}