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Involving patients in research design may increase enrollment and engagement, thereby enabling a means to relevant patient outcomes in clinical practice. Few data, however, illustrate attitudes of patients with dilated cardiomyopathy (DCM) and their family members toward genetic study design. This study assessed attitudes of 16 enrolled patients and their family members (P\/FM), and 18 investigators or researchers (I\/R) of the ongoing DCM Precision Medicine Study during a conjoint patient and investigator meeting using structured, self\u2010administered surveys examining direct\u2010to\u2010participant enrollment and web\u2010based consent, return of genetic results, and other aspects of genetic study design. Survey respondents were half women and largely identified as white. Web\u2010based consent was supported by 93% of P\/FM and 88% of I\/R. Most respondents believed that return of genetic results would motivate study enrollment, but also indicated a desire to opt out. Ideal study design preferences included a 1\u2010hour visit per year, along with the ability to complete study aspects by telephone or web and possibility of prophylactic medication. This study supports partnership of patients and clinical researchers to inform research priorities and study design to attain the promise of precision medicine for DCM.<\/jats:p>","DOI":"10.1111\/cts.12909","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T19:44:13Z","timestamp":1603827853000},"page":"550-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Attitudes of Dilated Cardiomyopathy Patients and Investigators Toward Genomic Study Enrollment, Consent Process, and Return of Genetic Results"],"prefix":"10.1111","volume":"14","author":[{"given":"Alisa D.","family":"Blazek","sequence":"first","affiliation":[{"name":"Division of Human Genetics Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D.","family":"Kinnamon","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyu","family":"Ni","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray E.","family":"Hershberger","sequence":"additional","affiliation":[{"name":"Division of Human Genetics &amp; Division of Cardiovascular Medicine Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-89"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.117.001826"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3218"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-017-0176-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154743"},{"key":"e_1_2_10_7_1","unstructured":"National Academies of Sciences Engineering and Medicine.Applying an implementation science approach to genomic medicine: workshop summary.Roundtable on Translating Genomic\u2010Based Research for Health. 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