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This study was designed to explore the association of<jats:italic>GST<\/jats:italic>and<jats:italic>ABCB1<\/jats:italic>genetic variation with hematologic and neurologic toxicity, changes in chemotherapy, and disease prognosis in Brazilian women with EOC. A total of 112 women with a confirmed histological diagnosis of EOC treated with carboplatin\/paclitaxel were enrolled (2014\u20132019). The samples were analyzed by multiplex polymerase chain reaction (PCR) for the deletion of<jats:italic>GSTM1<\/jats:italic>and<jats:italic>GSTT1<\/jats:italic>genes.<jats:italic>GSTP1<\/jats:italic>(c.313A&gt;G\/rs1695) and<jats:italic>ABCB1<\/jats:italic>(c.1236C&gt;T\/rs1128503; c.3435C&gt;T\/rs1045642; c.2677G&gt;T&gt;A\/rs2032582) single nucleotide polymorphisms (SNPs) were detected by real\u2010time PCR. Subjects with the<jats:italic>GSTP1<\/jats:italic>c.313A&gt;G had reduced risk of anemia (odds ratio (OR): 0.17, 95% confidence interval (CI): 0.04\u20130.69,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01, dominant model) and for thrombocytopenia (OR: 0.27, 95% CI: 0.12\u20130.64,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; OR 0.18, 95% CI 0.03\u20130.85,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03, either dominant or recessive model), respectively. The<jats:italic>GSTP1<\/jats:italic>c.313A&gt;G AG genotype was associated with a lower risk of dose delay (OR: 0.35, 95% CI: 0.13\u20130.90,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The<jats:italic>ABCB1<\/jats:italic>c.1236C&gt;T was associated with increased risk of thrombocytopenia (OR: 0.15, 95% CI: 0.03\u20130.82,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), whereas<jats:italic>ABCB1<\/jats:italic>c.3435C&gt;T had increased risk of grade 2 and 3 neurotoxicity (OR: 3.61, 95% CI: 1.08\u2013121.01,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) in recessive model (CC\u00a0+\u00a0CT vs. TT). This study suggests that<jats:italic>GSTP1<\/jats:italic>c.313A&gt;G,<jats:italic>ABCB1<\/jats:italic>c.1236C&gt;T, and c.3435C&gt;T SNP detection is a potential predictor of hematological toxicity and neurotoxicity and could help predict the clinical management of women with EOC.<\/jats:p>","DOI":"10.1111\/cts.12937","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T02:37:48Z","timestamp":1608172668000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<i>GSTP1<\/i>and<i>ABCB1<\/i>Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel\u2010Based Chemotherapy in Ovarian Cancer"],"prefix":"10.1111","volume":"14","author":[{"given":"Amanda Canato","family":"Ferracini","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medical Sciences Faculty of Medical Sciences University of Campinas Campinas 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