{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:28:25Z","timestamp":1760956105524},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration\/dose (C\/D) ratio is affected by CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which is frequently associated with end\u2010stage renal disease. Recently, PTH has been shown to downregulate CYP3A expression at mRNA level. In this study, we examined the influence of CYP3A5 polymorphism on and association of serum intact\u2010PTH (iPTH) level with blood tacrolimus concentration in patients with end\u2010stage renal disease just before kidney transplantation. Forty\u2010eight patients who satisfied the selection criteria were analyzed. Subjects were classified into two phenotype subgroups: CYP3A5 expressor (CYP3A5*1\/*1 and *1\/*3; <jats:italic>n<\/jats:italic>\u00a0=\u00a015) and CYP3A5 nonexpressor (CYP3A5*3\/*3; <jats:italic>n<\/jats:italic>\u00a0=\u00a033). The blood tacrolimus C\/D (per body weight) ratio was significantly lower in CYP3A5 expressors than that in CYP3A5 nonexpressors. A significant positive correlation was found between tacrolimus C\/D and iPTH concentrations (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.305, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.035), and the correlation coefficient was higher after excluding 20 patients co\u2010administered CYP3A inhibitor or inducer (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.428, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023). A multiple logistic regression analysis by stepwise selection identified CYP3A5 polymorphism and serum iPTH level as significant factors associated with tacrolimus C\/D. These results may suggest the importance of dose design considering not only the CYP3A5 phenotype but also serum iPTH level when using tacrolimus in patients who undergo renal transplantation.<\/jats:p>","DOI":"10.1111\/cts.13065","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T01:27:14Z","timestamp":1622510834000},"page":"2034-2042","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end\u2010stage renal disease"],"prefix":"10.1111","volume":"14","author":[{"given":"Ryota","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Medication Use Analysis and Clinical Research Meiji Pharmaceutical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Graduate School of Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Pharmaceutics Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutics Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadasuke","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Tatsuta","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Mimata","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Graduate School of Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Oita University Hospital Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2","article-title":"Annual Progress Report from the Japanese Renal Transplant Registry: number of renal transplantations in 2017 and a follow\u2010up survey","volume":"53","author":"Japanese Society for Clinical Renal Transplantation\/The Japan Society for Transplantation","year":"2018","journal-title":"JPN J Transplant"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181aa36cd"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1395413"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443100-00001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0282-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200112000-00005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.113"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026135317578"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1774"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.045245"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(03)00056-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2360-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.08.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00976"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544010-00002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.12.021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0146-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.208"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.59"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.62.01.0015"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.247"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.12.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.05.013"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820ae4ac"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1514-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000114747.08559.49"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12733"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.09.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200208000-00005"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181f3c063"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08020715"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.13065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:59:01Z","timestamp":1692953941000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/cts.13065"],"URL":"https:\/\/doi.org\/10.1111\/cts.13065","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}