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Metabolomic profiling, by studying the levels of numerous metabolic intermediates and products in the blood, allows a more detailed examination of metabolism dysfunctions. We aimed to identify blood metabolomic markers associated with weight gain in psychiatric patients. Sixty\u2010two patients starting a treatment known to induce weight gain were recruited. Two hundred and six selected metabolites implicated in various pathways were analyzed in plasma, at baseline and after 1\u00a0month of treatment. Additionally, 15 metabolites of the kynurenine pathway were quantified. This latter analysis was repeated in a confirmatory cohort of 24 patients. Among the 206 metabolites, a plasma metabolomic fingerprint after 1\u00a0month of treatment embedded 19 compounds from different chemical classes (amino acids, acylcarnitines, carboxylic acids, catecholamines, nucleosides, pyridine, and tetrapyrrole) potentially involved in metabolic disruption and inflammation processes. The predictive potential of such early metabolite changes on 3\u00a0months of weight evolution was then explored using a linear mixed\u2010effects model. Of these 19 metabolites, short\u2010term modifications of kynurenine, hexanoylcarnitine, and biliverdin, as well as kynurenine\/tryptophan ratio at 1\u00a0month, were associated with 3\u00a0months weight evolution. Alterations of the kynurenine pathway were confirmed by quantification, in both exploratory and confirmatory cohorts. Our metabolomic study suggests a specific metabolic dysregulation after 1\u00a0month of treatment with psychotropic drugs known to induce weight gain. The identified metabolomic signature could contribute in the future to the prediction of weight gain in patients treated with psychotropic drugs.<\/jats:p>","DOI":"10.1111\/cts.13122","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T13:14:05Z","timestamp":1628860445000},"page":"2544-2555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolomic alteration induced by psychotropic drugs: Short\u2010term metabolite profile as a predictor of weight gain evolution"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-857X","authenticated-orcid":false,"given":"Marie","family":"Lenski","sequence":"first","affiliation":[{"name":"Univ. 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