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Phosphate binders (calcium\u2010based and calcium free) are the mainstay pharmacologic treatment to lower phosphorus levels in patients with ESRD. We evaluated biochemical markers of vascular calcification, inflammation, and endothelial dysfunction in patients with chronic kidney disease (CKD) treated with sevelamer carbonate (SC) versus calcium acetate (CA). Fifty patients with CKD (stages 3 and 4) were enrolled and assigned to treatment with SC and CA for 12\u00a0weeks. At the end of the study the biomarkers of vascular calcification, inflammation, and endothelial dysfunction were analyzed. A significant increase in HDL\u2010cholesterol was observed with SC but not with CA in patients with CKD. Treatment with SC reduced serum phosphate, calcium phosphate, and FGF\u201023 levels and there was no change with CA treatment. The inflammatory markers IL\u20108, IFN\u2010\u03b3, and TNF\u03b1 decreased with response to both treatments. The levels of IL\u20106 significantly increased with CA treatment and no change was observed in the SC treatment group. SC showed favorable effects on anti\u2010inflammatory and vascular calcification biomarkers compared to CA treatment in patients with CKD stages 3 and 4 with normal phosphorous values.<\/jats:p>","DOI":"10.1111\/cts.13151","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T12:37:15Z","timestamp":1633351035000},"page":"353-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of sevelamer carbonate versus calcium acetate on vascular calcification, inflammation, and endothelial dysfunction in chronic kidney disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Darius L.","family":"Mason","sequence":"first","affiliation":[{"name":"Methodist Le Bonheur Healthcare  Memphis Tennessee USA"},{"name":"Department of Clinical Pharmacy &amp; Translational Science The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Godugu","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences  Rensselaer New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Nnani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Montefiore Medical Center The University Hospital for Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker A.","family":"Mousa","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences  Rensselaer New York 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