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In this prospective study, a total of 170 patients with acute STEMI who underwent PCI were divided into four groups: pantoprazole\u00a0+\u00a0ticagrelor, omeprazole\u00a0+\u00a0ticagrelor, ranitidine\u00a0+\u00a0ticagrelor, and ticagrelor only. The risk of PCI, antithrombotic efficacy, cardiac function, and main end points were evaluated and compared. No significant differences were found in infarction\u2010related artery perfusion indexes (thrombolysis in myocardial infarction [TIMI], corrected TIMI frame count), the incidence of stent thrombosis after PCI, platelet indicators (platelet count, mean platelet volume, and platelet distribution width), platelet activation (P\u2010selectin and glycoprotein IIb\/IIIa levels), platelet aggregation (thrombelastography indicators, such as ADP% and MA<jats:sub>ADP<\/jats:sub>), myocardial necrosis biomarker (creatine kinase isoenzyme\u2010MB and cardiac troponin I) levels, brain natriuretic peptide levels, the incidence of ischemic end point events, and the incidence of other tissue and organ bleeding events among the four groups. The incidence of gastrointestinal (GI) bleeding events in the proton pump\u2010inhibitor (PPI) group was significantly lower than that in the control group, whereas in the H2 receptor antagonist (H2RA) group it was not significantly different from the control group. The short\u2010term combination therapy with ticagrelor and PPIs or H2RA is safe and effective in patients with acute STEMI after PCI. In addition, the PPIs combined with ticagrelor could reduce the incidence of GI bleeding events without increasing the incidence of ischemic events.<\/jats:p>","DOI":"10.1111\/cts.13165","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T03:24:07Z","timestamp":1634786647000},"page":"477-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The efficacy and safety of the short\u2010term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI"],"prefix":"10.1111","volume":"15","author":[{"given":"Peng","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiang","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hainan Provincial Hospital of Traditional Chinese Medicine  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Xuzhou School of Clinical Medicine of Nanjing Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Xuzhou School of Clinical Medicine of Nanjing Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Xuzhou School of Clinical Medicine of Nanjing Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangming","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yantai Affiliated 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