{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:56:09Z","timestamp":1789232169959,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID\u201019), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV\u2010ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC\u2010CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug\u2010induced CV\u2010ADRs from COVID\u201019 effects, we restricted analyses to patients with COVID\u201019 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08\u20133.29), bradycardia (aOR: 2.09, 95% CI: 1.24\u20133.53), and hypotension (aOR: 1.67, 95% CI: 1.03\u20132.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC\u2010CMs in time\u2010 and dose\u2010dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin.<\/jats:p>","DOI":"10.1111\/cts.13168","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T17:56:53Z","timestamp":1635703013000},"page":"501-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-563X","authenticated-orcid":false,"given":"Se Yong","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min 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Parc Sanitari Sant Joan de D\u00e9u Universitat de Barcelona Fundaci\u00f3 Sant Joan de D\u00e9u CIBERSAM  Barcelona Spain"},{"name":"ICREA  Barcelona Spain"},{"name":"Instituto de Salud Carlos III Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental CIBERSAM  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Mental Health The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-2946","authenticated-orcid":false,"given":"Andreas","family":"Kronbichler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Medical University Innsbruck  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