{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:52:46Z","timestamp":1779306766879,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Junctional ectopic tachycardia (JET) is a potentially life\u2010threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at\u2010risk populations. In adults, \u03b21\u2010adrenergic receptor (<jats:italic>ADRB1<\/jats:italic>) and \u03b22\u2010adrenergic receptor (<jats:italic>ADRB2<\/jats:italic>) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between <jats:italic>ADRB1<\/jats:italic> and <jats:italic>ADRB2<\/jats:italic> genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the <jats:italic>ADRB1<\/jats:italic> p.Ser49Gly (rs1801252; c.145A&gt;G), p.Arg389Gly (rs1801253; c.1165C&gt;G), <jats:italic>ADRB2<\/jats:italic> p.Arg16Gly (rs1042713; c.46A&gt;G), and p.Glu27Gln (rs1042714; c.79G&gt;C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist\u2010interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a \u03b2\u2010blocker. Of the 343 children included (median age 8\u00a0months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR]\u00a0=\u00a01.96, 95% confidence interval [CI]\u00a0=\u00a00.96\u20134.03, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.064), but was nominally associated in patients not taking a \u03b2\u2010blocker (<jats:italic>n<\/jats:italic>\u00a0=\u00a0324, OR\u00a0=\u00a02.25, 95% CI\u00a0=\u00a01.05\u20134.80. <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034). None of the other variants were associated with JET. These data suggest that the <jats:italic>ADRB1<\/jats:italic> Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of \u03b2\u2010blockade. Whether treatment with a \u03b2\u2010blocker ameliorates this association requires further research.<\/jats:p>","DOI":"10.1111\/cts.13178","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T10:36:20Z","timestamp":1635503780000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u03b21\u2010receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery"],"prefix":"10.1111","volume":"15","author":[{"given":"Leanne","family":"Dumeny","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marut","family":"Chantra","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Departments of Pediatrics College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taimour","family":"Langaee","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Q.","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Departments of Surgery and Pediatrics Congenital Heart Center College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Lopez\u2010Colon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Departments of Surgery and Pediatrics Congenital Heart Center College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Humma","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Dacosta","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommie","family":"Lovato","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio D.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giles J.","family":"Peek","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Departments of Surgery and Pediatrics Congenital Heart Center College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Departments of Surgery and Pediatrics Congenital Heart Center College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Bleiweis","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Departments of Surgery and Pediatrics Congenital Heart Center College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa H.","family":"Cavallari","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida  Gainesville Florida 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