{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T21:45:29Z","timestamp":1770673529462,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM008562"],"award-info":[{"award-number":["T32GM008562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is unclear if the pharmacokinetics of vancomycin are the same during automated peritoneal dialysis (APD), where cycler exchanges may affect the systemic, peritoneal, and urinary disposition of drug. We conducted a prospective pharmacokinetic study evaluating the pharmacokinetics of vancomycin in plasma, dialysis fluid, and urine in peritonitis\u2010negative patients on APD. Patients underwent four drug\u2010free exchanges with 1.5% or 2.5% dextrose following the initial dwell period. Plasma, dialysis fluid, and urine was collected over the course of 7\u00a0days for pharmacokinetic analysis. Four patients completed the study with no adverse events. Following a median (range) dwell of 14.6 (14.2\u201317.6\u00a0h), the mean (\u00b1SD) observed maximum plasma concentration was 28.7\u00a0\u00b1\u00a04.9\u00a0mg\/L with a mean bioavailability of 98.5\u00a0\u00b1\u00a01.4% prior to starting the cycler. The overall mean total plasma clearance estimated from study start to completion was 7.6\u00a0\u00b1\u00a01.2\u00a0ml\/min. Mean total clearance during the dialytic exchange was 13.6\u00a0\u00b1\u00a04.9\u00a0ml\/min. In patients with residual renal function, the mean vancomycin renal clearance was 3.1\u00a0\u00b1\u00a01.5\u00a0ml\/min, representing 21.4%\u201358.9% of the overall total plasma clearance during the study period. Despite the small sample size, this pilot study suggests that the dwell time has important implications for systemic vancomycin exposure, time to therapeutic plasma concentration, and dosing. Dose is driven by dwell time, whereas the cycler determines the dosing interval. Rapid exchanges from APD will determine the frequency of dosing rather than the adequacy of absorption when vancomycin is given in the peritoneum.<\/jats:p>","DOI":"10.1111\/cts.13182","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:40:18Z","timestamp":1636530018000},"page":"649-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intraperitoneal pharmacokinetics of vancomycin in patients on automated peritoneal dialysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Edwin","family":"Lam","sequence":"first","affiliation":[{"name":"Clinical Pharmacokinetics Research Lab National Institutes of Health  Bethesda Maryland USA"},{"name":"Department of Pharmacology &amp; Experimental Therapeutics Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ting (Kayla) Lien","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology College of Pharmacy University of Florida  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter K.","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Experimental Therapeutics Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas F.","family":"Stickle","sequence":"additional","affiliation":[{"name":"Department of Pathology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Piraino","sequence":"additional","affiliation":[{"name":"Renal Electrolyte Division School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"System.USRDS annual data report: epidemiology of kidney disease in the United States;2020."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00185"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00131"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2018.00030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0896860819889774"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.89"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080102100408"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.726"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa036"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.13182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:11:59Z","timestamp":1693105919000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/cts.13182"],"URL":"https:\/\/doi.org\/10.1111\/cts.13182","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"2021-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}