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Yet, owing to the unique life cycle of <jats:italic>Strongyloides stercoralis<\/jats:italic> (<jats:italic>S. stercoralis<\/jats:italic>) that entails internal autoinfection, a curative treatment would be desirable. Population\u2010based pharmacometric modeling that would help to identify an ideal dosing strategy are yet lacking. The aims of this study were to (i) explore the exposure\u2010efficacy response relationship of moxidectin in treating <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> and (ii) evaluate whether moxidectin treatment outcomes in terms of cure rates at baseline as compared to post\u2010treatment could be optimized. Our pharmacodynamic model suggests high predictive power (area under the concentration time curve\u2010receiver operating characteristic [AUC\u2010ROC] 0.817) in the probability of being cured by linking an exposure metric (i.e., AUC<jats:sub>0\u201024<\/jats:sub> or maximum concentration [C<jats:sub>max<\/jats:sub>]) to baseline infection intensity. Pharmacometric simulations indicate that with a minimum dose of 4\u00a0mg a maximum cure rate of ~\u00a095% is established in the low infection intensity group (larvae per gram [LPG] \u22650.4\u20131), whereas in the moderate\u2010to\u2010high intensity group (LPG &gt;1) the cure rate plateaus at ~\u00a087%, following an 8\u00a0mg dose. To enhance efficacy further, studies using repeated dosing based on the duration of the autoinfection cycle, for example a two\u2010dose regimen 3\u00a0weeks apart should be considered. Simulations revealed similar C<jats:sub>max<\/jats:sub> in both treatment courses of a two\u2010dose regimen; hence safety should not be a concern. Collectively, our results provide evidence\u2010based guidance for enhanced dosing strategies and should be considered when designing future treatment strategies.<\/jats:p>","DOI":"10.1111\/cts.13189","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T06:46:43Z","timestamp":1639118803000},"page":"700-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Optimizing moxidectin dosing for <i>Strongyloides stercoralis<\/i> infections: Insights from pharmacometric modeling"],"prefix":"10.1111","volume":"15","author":[{"given":"Daniela","family":"Hofmann","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology Swiss Tropical and Public Health Institute University of Basel  Basel Switzerland"},{"name":"University of Basel  Basel 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