{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T02:29:11Z","timestamp":1785637751007,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, potentially life\u2010threatening, delayed, drug\u2010induced hypersensitivity reaction. Immediate withdrawal of the culprit drug and administration of systemic corticosteroids is the most widely accepted treatment. However, it is difficult to manage patients with DRESS syndrome who are not responsive to systemic steroids. We studied the efficacy of intravenous immunoglobulins (IVIGs) in patients with DRESS syndrome unresponsive to systemic steroids. We retrospectively reviewed patients with DRESS syndrome who received IVIG in addition to systemic steroids during 2012\u20132017 and compared the clinical features and course of DRESS syndrome, before and after IVIG treatment. Eighteen DRESS patients (9 men) were included. The most frequent offending drugs were dapsone in five patients, followed by vancomycin in three patients, and carbamazepine in three patients. Rash, fever, lymphadenopathy, atypical lymphocytes, and hepatic involvement were common clinical findings. IVIG treatment was added within a median time of 7\u00a0days from the commencement of systemic steroid therapy. After IVIG treatment (total dosage: 1\u20132\u00a0g\/kg), the fever resolved within a median time of 1\u00a0day (range, 0\u20133) and liver enzymes improved substantially within a median time of 13\u00a0days (range, 0\u201327). No severe adverse reactions related to IVIG therapy were observed in this study; however, there was one case of mortality. The addition of IVIG in DRESS syndrome in cases refractory to systemic steroid treatment may be helpful in hastening recovery. However, comparative studies using a placebo group are needed.<\/jats:p>","DOI":"10.1111\/cts.13201","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T07:58:01Z","timestamp":1637308681000},"page":"782-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of add\u2010on therapy with intravenous immunoglobulin in steroid hyporesponsive DRESS syndrome"],"prefix":"10.1111","volume":"15","author":[{"given":"Da Woon","family":"Sim","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Department of Internal Medicine Chonnam National University Medical School Chonnam National University Hospital  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Department of Internal Medicine Chonnam National University Medical School Chonnam National University Hospital  Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Il","family":"Koh","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Clinical Immunology Department of Internal Medicine Chonnam National University Medical School Chonnam National University Hospital  Gwangju 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