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However, curves describing the growth of a typical population of children may not accurately characterize growth of children with various conditions, such as obesity. Therefore, to develop height and weight versus age growth curves for youth who were diagnosed with type 2 diabetes, we extracted data from electronic medical records. Robust nonlinear models were parameterized to the equations describing height and weight versus age as defined by the Centers for Disease Control and Prevention (CDC). CDC z\u2010scores were calculated using an internal program. The growth curves and z\u2010scores were compared to CDC norms. Youth with type 2 diabetes were increasingly heavier than CDC norms from early childhood. Except for a period around puberty, youth with type 2 diabetes were, on average, shorter than CDC norms, resulting in shorter average adult height. Deviations in growth were apparent in youth who develop type 2 diabetes; such deviations may be expected for other conditions as well, and disease\u2010specific growth curves should be considered during development of model\u2010informed drug development for pediatric conditions.<\/jats:p>","DOI":"10.1111\/cts.13207","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T06:45:42Z","timestamp":1647499542000},"page":"912-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric growth patterns in youth\u2010onset type 2 diabetes mellitus: Implications for physiologically\u2010based pharmacokinetic models"],"prefix":"10.1111","volume":"15","author":[{"given":"Chelsea M.","family":"Hosey","sequence":"first","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsee","family":"Halpin","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Shakhnovich","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"},{"name":"University of Kansas Medical Center Kansas City Kansas USA"},{"name":"Center for Children\u2019s Healthy Lifestyles &amp; Nutrition Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengpeng","family":"Bi","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"},{"name":"Center for Children\u2019s Healthy Lifestyles &amp; Nutrition Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yan","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Kansas City Kansas City Missouri USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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