{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:55:14Z","timestamp":1770836114861,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR001445\u201006A1"],"award-info":[{"award-number":["UL1 TR001445\u201006A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005481","name":"School of Medicine, New York University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Randomized controlled trials (RCTs) remain the gold standard to evaluate clinical interventions, producing the highest level of evidence while minimizing potential bias. Inadequate recruitment is a commonly encountered problem that undermines the completion and generalizability of RCTs\u2014and is even more challenging when enrolling amidst a pandemic. Here, we reflect on our experiences with virtual recruitment of non\u2010hospitalized patients in the United States for ColCorona, an international, multicenter, randomized, placebo\u2010controlled coronavirus disease 2019 (COVID\u201019) drug trial. Recruitment challenges during a pandemic include constraints created by shelter\u2010in\u2010place policies and targeting enrollment according to national and local fluctuations in infection rate. Presenting a study to potential participants who are sick with COVID\u201019 and may be frightened, overwhelmed, or mistrusting of clinical research remains a challenge. Strategies previously reported to improve recruitment include transparency, patient and site education, financial incentives, and person\u2010to\u2010person outreach. Active measures taken during ColCorona to optimize United States recruitment involved rapid expansion of sites, adjustment of recruitment scripts, assessing telephone calls versus text messages for initial contact with participants, institutional review board\u2010approved financial compensation, creating an infrastructure to systematically identify potentially eligible patients, partnering with testing sites, appealing to both self\u2010interest and altruism, and large\u2010scale media efforts with varying degrees of success.<\/jats:p>","DOI":"10.1111\/cts.13211","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T06:39:17Z","timestamp":1640414357000},"page":"831-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chasing the storm: Recruiting non\u2010hospitalized patients for a multi\u2010site randomized controlled trial in the United States during the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"15","author":[{"given":"Kelly","family":"Hu","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Huber","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Daly","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha\u00a0T.","family":"Langford","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Kirby","sequence":"additional","affiliation":[{"name":"National Heart Lung Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"National Heart Lung Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Hochman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NYU Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avni","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Immunology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohar","family":"Bassevitch","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Pillinger","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Medicine NYU Grossman School of Medicine  New York New York USA"},{"name":"Section of Rheumatology Department of Medicine United States Department of Veterans Affairs  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binita","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NYU Grossman School of Medicine  New York New York USA"},{"name":"Section of Cardiology Department of Medicine United States Department of Veterans Affairs  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0b013e3182306440"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00222-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.6.1728"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.08.043"},{"key":"e_1_2_9_6_1","first-page":"MR000013\u2010MR","article-title":"Strategies to improve recruitment to randomised trials","volume":"2","author":"Treweek S","year":"2018","journal-title":"Cochrane Database Syst 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CDC: Centers for Disease Control and Prevention.https:\/\/covid.cdc.gov\/covid\u2010data\u2010tracker\/#county\u2010view. Accessed May 4 2021."}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.13211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:00:34Z","timestamp":1692972034000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,24]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/cts.13211"],"URL":"https:\/\/doi.org\/10.1111\/cts.13211","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,24]]},"assertion":[{"value":"2021-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}