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We investigated the impact of the various DDIs classified as severe in terms of emergency admissions in the elderly. A cross\u2010sectional study was conducted using information from the emergency department admissions of Bordeaux University Hospital between September 2016 and August 2017. Events of interest were frequency of concomitant uses of interacting drugs that are contraindicated or warned against and frequency of emergency admissions due to contraindicated or warned against concomitant uses of interacting drugs. Five thousand, eight hundred sixty (5860) admissions to the emergency department were analyzed. A total of 375 (6.4%) contraindicated or warned against concomitant uses were identified, including 163 contraindicated (43.5%) and 212 warned against (56.5%). Reason for admission appeared likely related to the underlying DDI in 58 cases. Within these, 36 admissions were assessed as probably due to a DDI (0.6% of hospitalizations) and 22 as certainly (0.4% of hospitalizations). Of these, there were 24 (45%) admissions related to a long QT syndrome (LQTS), nine (16%) related to a drug overdose, and eight (14%) related to a hemorrhage. An antidepressant was involved in 22 of the 24 cases of LQTS. Seven of the eight cases of hemorrhage involved the antithrombotic agents \/ non\u2010steroidal anti\u2010inflammatory drugs combination. Elderly patients admitted to emergency departments are particularly exposed to high\u2010risk potential DDIs. These drug combinations lead mainly to LQTS and involve certain antidepressants.<\/jats:p>","DOI":"10.1111\/cts.13262","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T14:47:33Z","timestamp":1646405253000},"page":"1472-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Emergency department admissions induced by drug\u2013drug interactions in the elderly: A cross\u2010sectional study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-4866","authenticated-orcid":false,"given":"Louis","family":"Letinier","sequence":"first","affiliation":[{"name":"INSERM BPH, U1219 Team Pharmacoepidemiology Univ. 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