{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:07Z","timestamp":1788779527222,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Effects of\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    *6 and\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    *28 genetic polymorphisms on irinotecan\u2010induced severe toxicities in Asian cancer patients are inconclusive. Also,\n                    <jats:italic>ABCC2 c.3972C&gt;T<\/jats:italic>\n                    may affect toxicity of irinotecan. The aim was to assess the aggregated risk of neutropenia or diarrhea in Asian cancer patients taking irinotecan and inherited\n                    <jats:italic>UGT1A1*6<\/jats:italic>\n                    ,\n                    <jats:italic>UGT1A1*28,<\/jats:italic>\n                    or\n                    <jats:italic>ABCC2 c.3972C&gt;T<\/jats:italic>\n                    genetic variants. A PubMed literature search for eligible studies was conducted. Odds ratios (ORs) were measured using RevMan software where\n                    <jats:italic>p<\/jats:italic>\n                    values &lt;0.05 were statistically significant. Patients that inherited both\n                    <jats:italic>UGT1A1*6<\/jats:italic>\n                    and\n                    <jats:italic>UGT1A1*28<\/jats:italic>\n                    genetic variants (heterozygous:\n                    <jats:italic>UGT1A1*1\/*6<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>*1\/*28<\/jats:italic>\n                    and homozygous:\n                    <jats:italic>UGT1A1*6\/*6<\/jats:italic>\n                    \u2009+\u2009\n                    <jats:italic>*28\/*28<\/jats:italic>\n                    ) were significantly associated with increased risk of neutropenia and diarrhea compared to patients with\n                    <jats:italic>UGT1A1*1\/*1<\/jats:italic>\n                    (neutropenia: OR 2.89; 95% CI 1.97\u20134.23;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001; diarrhea: OR 2.26; 95% CI 1.71\u20132.99;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001). Patients carrying homozygous variants had much stronger effects in developing toxicities (neutropenia: OR 6.23; 95% CI 3.11\u201312.47;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001; diarrhea: OR 3.21; 95% CI 2.13\u20134.85;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001) than those with heterozygous variants. However, patients carrying the\n                    <jats:italic>ABCC2 c.3972C&gt;T<\/jats:italic>\n                    genetic variant were not significantly associated with neutropenia (OR 1.67; 95% CI 0.98\u20132.84;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.06) and were significantly associated with a reduction in irinotecan\u2010induced diarrhea (OR 0.31; 95% CI 0.11\u20130.81;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.02). Asian cancer patients should undergo screening for both\n                    <jats:italic>UGT1A1*6<\/jats:italic>\n                    and\n                    <jats:italic>UGT1A1*28<\/jats:italic>\n                    genetic variants to reduce substantially irinotecan\u2010induced severe toxicities.\n                  <\/jats:p>","DOI":"10.1111\/cts.13277","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T02:15:06Z","timestamp":1651630506000},"page":"1613-1633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of\n                    <i>UGT1A1*6<\/i>\n                    ,\n                    <i>UGT1A1*28<\/i>\n                    , or\n                    <i>ABCC2 c.3972C&gt;T<\/i>\n                    genetic polymorphisms with irinotecan\u2010induced toxicity in Asian cancer patients: Meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Chalirmporn","family":"Atasilp","sequence":"first","affiliation":[{"name":"Chulabhorn International College of Medicine Thammasat University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohitosh","family":"Biswas","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"},{"name":"Department of Pharmacy University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimonpan","family":"Jinda","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutthan","family":"Nuntharadthanaphong","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiratha","family":"Rachanakul","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowaluck","family":"Hongkaew","sequence":"additional","affiliation":[{"name":"Advance Research and Development Laboratory Bumrungrad International Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natchaya","family":"Vanwong","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Faculty of Allied Health Sciences Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surasak","family":"Saokaew","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Practice, Department of Pharmaceutical Care School of Pharmaceutical Sciences, University of Phayao  Phayao Thailand"},{"name":"Center of Health Outcomes Research and Therapeutic Safety (COHORTS) School of Pharmaceutical Sciences, University of Phayao  Phayao Thailand"},{"name":"Unit of Excellence on Clinical Outcomes Research and Integration (UNICORN) School of Pharmaceutical Sciences, University of Phayao  Phayao Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"},{"name":"Pharmacogenomics and Precision Medicine, The Preventive Genomics &amp; Family Check\u2010up Services Center Bumrungrad International Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02034-1"},{"issue":"10","key":"e_1_2_9_4_1","first-page":"1157","article-title":"Bioactivation of the anticancer agent CPT\u201011 to SN\u201038 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions","volume":"25","author":"Slatter JG","year":"1997","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"e_1_2_9_5_1","first-page":"52","article-title":"Irinotecan treatment in cancer patients with UGT1A1 polymorphisms","volume":"17","author":"Innocenti F","year":"2003","journal-title":"Oncology (Williston Park)"},{"issue":"8","key":"e_1_2_9_6_1","first-page":"2182","article-title":"Clinical pharmacokinetics and metabolism of irinotecan (CPT\u201011)","volume":"7","author":"Mathijssen RH","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.126"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511023331802"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.143"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1122"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520611313020008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23370"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500072"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2015.12.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.5400"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2013.10"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm115"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3306-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000173483.13689.56"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2382-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0604-x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0821-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2046"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.12.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00541.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr001"},{"key":"e_1_2_9_28_1","first-page":"3677","article-title":"Relationship between UGT1A1*6\/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan\u2010containing regimens","volume":"9","author":"Yang C","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2013.105"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13807"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1703-1"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S137644"},{"issue":"10","key":"e_1_2_9_33_1","first-page":"2757","article-title":"Effects of ABCC2 and SLCO1B1 polymorphisms on treatment responses in Thai metastatic colorectal cancer patients treated with irinotecan\u2010based chemotherapy","volume":"19","author":"Treenert A","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500403"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22760"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70351-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2405-0"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13028"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3344-3"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2013.867534"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200576"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2010"},{"key":"e_1_2_9_44_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G","year":"2021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1792871"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-9-199711010-00008"},{"key":"e_1_2_9_47_1","unstructured":"HigginsJPT ThomasJ ChandlerJ CumpstonM LiT.Cochrane Handbook for Systematic Reviews of Interventions Version 6.0.2021."},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7249.1574"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0630-8"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1140-z"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13757"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337989"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(17)30024-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328014341f"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3406-2"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07225-1"},{"key":"e_1_2_9_57_1","first-page":"1653","article-title":"Clinical significance of UGT1A1 gene polymorphisms on irinotecan\u2010based regimens as the treatment in metastatic colorectal cancer","volume":"7","author":"Li M","year":"2014","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318200e4e8"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq435"},{"issue":"9","key":"e_1_2_9_60_1","first-page":"1339","article-title":"UGT1A1 gene polymorphism predicts irinotecan\u2010induced severe neutropenia and diarrhea in Chinese cancer patients","volume":"63","author":"Peng H","year":"2017","journal-title":"Clin Lab"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02030.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12303"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01227-w"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1485-8"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-1981-0"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1159\/000209335"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-00917-5"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i45.6635"},{"issue":"5","key":"e_1_2_9_69_1","first-page":"5743","article-title":"Distribution of uridine diphosphate glucuronosyltransferase 1A polymorphisms and their role in irinotecan\u2010induced toxicity in patients with cancer","volume":"14","author":"Wang Y","year":"2017","journal-title":"Oncol Lett"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S95149"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3057-z"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13333"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.June.29.17"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.152"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.7.3335"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.145871"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-020-01045-7"},{"key":"e_1_2_9_78_1","unstructured":"DeanL.Irinotecan therapy and UGT1A1 genotype.Medical Genetics Summaries.2021."},{"issue":"5","key":"e_1_2_9_79_1","first-page":"923","article-title":"Prevalence of topoisomerase I genetic mutations and UGT1A1 polymorphisms associated with irinotecan in individuals of Asian descent","volume":"2","author":"Fukui T","year":"2011","journal-title":"Oncol Lett"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12117"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S108656"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.13277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:17:17Z","timestamp":1694877437000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/cts.13277"],"URL":"https:\/\/doi.org\/10.1111\/cts.13277","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.163251919.96567590\/v1","asserted-by":"object"}]},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"2021-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}