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Literature was searched in different databases following PRISMA guidelines. The outcomes were measured as odds ratio (OR) using RevMan software by a random\/fixed effects model, where p<\/jats:italic>\u00a0<\u00a00.05 was set as statistical significance. In total, 46 case\u2013control studies met the inclusion criteria and were included in this analysis consisting of 1817 cases and 6614 controls. It was found that case\u2010patients who carried the HLA\u2010B*15:02<\/jats:italic> allele were associated with a significantly increased risk of CBZ\u2010induced Stevens\u2212Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) compared to controls (OR 26.01; 95% CI 15.88\u201342.60; p<\/jats:italic>\u00a0<\u00a00.00001). The aggregated risk of cADRs was slightly higher in Asian compared to Caucasian patients (Asians: OR 14.84; 95% CI 8.95\u201324.61; p<\/jats:italic>\u00a0<\u00a00.00001; Caucasians: OR 11.65; 95% CI 1.68\u201380.70; p<\/jats:italic>\u00a0=\u00a00.01). Further, HLA\u2010B*15:11<\/jats:italic>, HLA\u2010B*15:21<\/jats:italic>, or HLA\u2010A*31:01<\/jats:italic> allele was also associated with significantly increased risk of CBZ\u2010induced cADRs (HLA\u2010B*15:11:<\/jats:italic> OR 6.08; 95% CI 2.28\u201316.23; p<\/jats:italic>\u00a0=\u00a00.0003; HLA\u2010B*15:21:<\/jats:italic> OR 5.37; 95% CI 2.02\u201314.28; p<\/jats:italic>\u00a0=\u00a00.0008; HLA\u2010A*31:01:<\/jats:italic> OR 5.92; 95% CI 4.35\u20138.05; p<\/jats:italic>\u00a0<\u00a00.00001). Other HLA<\/jats:italic> variants were not found to have any significant associations with CBZ\u2010induced cADRs. Strong associations between the HLA\u2010B*15:02<\/jats:italic>, HLA\u2010B*15:11<\/jats:italic>, HLA\u2010B*15:21<\/jats:italic>, or HLA\u2010A*31:01<\/jats:italic> allele with CBZ\u2010induced cADRs have been established in this analysis. Pharmacogenetic testing of particular HLA<\/jats:italic> alleles before initiation of CBZ therapy may be beneficial to patients and may help to eradicate cADRs substantially.<\/jats:p>","DOI":"10.1111\/cts.13291","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T02:41:01Z","timestamp":1653273661000},"page":"1887-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Associations of HLA<\/i> genetic variants with carbamazepine\u2010induced cutaneous adverse drug reactions: An updated meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-7701","authenticated-orcid":false,"given":"Mohitosh","family":"Biswas","sequence":"first","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand"},{"name":"Laboratory 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