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In adults, propafenone adverse events (AEs) are associated with CYP2D6 poor metabolizer status; however, pediatric data are lacking. Subjects were tested for 10 <jats:italic>CYP2D6<\/jats:italic> allelic variants and copy number status, and activity scores assigned to each genotype. Seventy\u2010six individuals (median 0.3 [range 0\u201326] years old) were included. Propafenone AEs occurred in 29 (38%); 14 (18%) required drug discontinuation due to AE. The most common AEs were QRS (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and QTc (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) prolongation. Those with AEs were older at the time of propafenone initiation (1.58 [0.13\u20139.92] vs. 0.20 [0.08\u20132.01] years old; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.042). CYP2D6 activity scores were not associated with presence of an AE (odds ratio [OR] 0.48 [0.22\u20131.03]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.055) but with the total number of AE (<jats:italic>\u03b2<\/jats:italic><jats:sub>1<\/jats:sub>\u00a0=\u00a0\u22120.31 [\u22120.60, \u22120.03]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), systemic AEs (OR 0.33 [0.13\u20130.88]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.022), and drug discontinuation for systemic AEs (OR 0.28 [0.09\u20130.83]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017). Awareness of CYP2D6 activity score and patient age may aid in determining an individual's risk for an AE with propafenone administration.<\/jats:p>","DOI":"10.1111\/cts.13296","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T06:49:32Z","timestamp":1651819772000},"page":"1787-1795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of <i>CYP2D6<\/i> genetic variation on adverse events with propafenone in the pediatric and young adult population"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-8204","authenticated-orcid":false,"given":"Sudeep D.","family":"Sunthankar","sequence":"first","affiliation":[{"name":"Thomas P. 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