{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:31Z","timestamp":1791919471029,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>ABCG2<\/jats:italic> is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G&gt;T, a single nucleotide polymorphism of the <jats:italic>ABCG2<\/jats:italic> gene, is associated with gout and poor response to allopurinol, a uric acid\u2010lowering agent used to treat this condition. It has also been suggested that oxypurinol, the primary active metabolite of allopurinol, is a substrate of the BCRP. We thus hypothesized that carrying the rs2231142 variant would be associated with decreased oxypurinol concentrations, which would explain the lower reduction in uric acid. We performed a cross\u2010sectional study to investigate the association between the <jats:italic>ABCG2<\/jats:italic> rs2231142 variant and oxypurinol, allopurinol, and allopurinol riboside concentrations in 459 participants from the Montreal Heart Institute Hospital Cohort. Age, sex, weight, use of diuretics, and estimated glomerular filtration rate were all significantly associated with oxypurinol plasma concentration. No association was found between rs2231142 and oxypurinol, allopurinol and allopurinol riboside plasma concentrations. Rs2231142 was not significantly associated with daily allopurinol dose in the overall population, but an association was observed in men, with T carriers receiving higher doses. Our results do not support a major role of <jats:italic>ABCG2<\/jats:italic> in the pharmacokinetics of allopurinol or its metabolites. The underlying mechanism of the association between rs2231142 and allopurinol efficacy requires further investigation.<\/jats:p>","DOI":"10.1111\/cts.13318","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T05:38:15Z","timestamp":1654925895000},"page":"2024-2034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["An association study of <scp><i>ABCG2<\/i><\/scp> rs2231142 on the concentrations of allopurinol and its metabolites"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-6151","authenticated-orcid":false,"given":"Marc\u2010Olivier","family":"Pilon","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Montreal Heart Institute  Montreal Quebec Canada"},{"name":"Universit\u00e9 de Montreal Beaulieu\u2010Saucier Pharmacogenomics Center  Montreal Quebec 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