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Therefore, we sought to identify lipidomic biomarkers associated with the time\u2010varying differences in CY formation clearance to 4\u2010hydroxycyclophosphamide (4HCY), the principal precursor to CY's cytotoxic metabolite. Hematopoietic cell transplant (HCT) patients receiving post\u2010transplant CY (PT\u2010CY) were enrolled, cohort 1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) and cohort 2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) donating longitudinal blood samples before they started HCT (pre\u2010HCT), before infusion of the donor allograft (pre\u2010graft), before the first dose of PT\u2010CY (pre\u2010CY) and 24\u2009h after the first dose of PT\u2010CY (24\u2010h post\u2010CY) which is also immediately before the second dose of CY. A total of 409 and 387 lipids were quantitated in the two cohorts, respectively. Associations between lipids, individually and at a class level, and the ratio of 4HCY\/CY AUC (i.e., 4HCY formation clearance) were evaluated using linear regression with a false discovery rate &lt;0.05. There were no individual lipids that passed control for false discovery at any time point. These results demonstrate the feasibility of lipidomics, but future studies in larger samples with multiple omic tools are warranted to optimize CY dosing in HCT.<\/jats:p>","DOI":"10.1111\/cts.13404","type":"journal-article","created":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T20:04:56Z","timestamp":1662926696000},"page":"2772-2780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lipidomics of cyclophosphamide 4\u2010hydroxylation in patients receiving post\u2010transplant cyclophosphamide"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-2486","authenticated-orcid":false,"given":"Sandi L.","family":"Navarro","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences Fred Hutchinson Cancer Center  Seattle Washington 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