{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:17:29Z","timestamp":1777303049343,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["18183MFDS492"],"award-info":[{"award-number":["18183MFDS492"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sugammadex, a selective antagonist of steroidal non\u2010depolarizing neuromuscular blocking agents, has been used in children in limited circumstances. However, neither pharmacokinetics (PKs) nor recovery profile of sugammadex for intense neuromuscular blockade reversal in children have been reported. This prospective study aimed to obtain a PK model of sugammadex and evaluate its efficacy and safety for intense neuromuscular blockade reversal in children. Forty children (age, 2\u201317\u2009years) who underwent surgery that required early neuromuscular blockade reversal were enrolled. After neuromuscular blockade with 1\u00a0mg\u2219kg<jats:sup>\u22121<\/jats:sup> of rocuronium, sugammadex (2, 4, and 8\u00a0mg\u2219kg<jats:sup>\u22121<\/jats:sup>) or a conventional dose of neostigmine (0.03\u2009mg\u2219kg<jats:sup>\u22121<\/jats:sup>) was administered randomly after confirmation of zero post\u2010tetanic count. The plasma concentrations of rocuronium and sugammadex were measured 2\u00a0min after rocuronium injection; immediately before, 2, 5, 15, 60, 120, 240, and 480\u2009min after the study drug injection. Response to train\u2010of\u2010four stimulation was continuously recorded. Noncompartmental analysis and population PK modeling were performed. For pharmacodynamics, the recovery profile was measured. Three\u2010compartment PK model was established for sugammadex. The median (interquartile range [IQR]) time from injection of 8\u00a0mg\u2219kg<jats:sup>\u22121<\/jats:sup> of sugammadex to recovery of <jats:italic>T<\/jats:italic><jats:sub>4<\/jats:sub>\/<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>greater than or equal to 0.9 at train\u2010of\u2010four stimulation was 1.1 (IQR: 0.88\u20131.8) min. No adverse events related to sugammadex were observed. We present a PK analysis of sugammadex for rocuronium\u2010induced intense neuromuscular blockade reversal in children with its recovery profile. The time to recover <jats:italic>T<\/jats:italic><jats:sub>4<\/jats:sub>\/<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> greater than or equal to 0.9 at train\u2010of\u2010four stimulation with 8\u00a0mg\u2219kg<jats:sup>\u22121<\/jats:sup> of sugammadex was less than 3\u00a0min and comparable to that in adults.<\/jats:p>","DOI":"10.1111\/cts.13429","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T08:18:10Z","timestamp":1664612290000},"page":"92-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reversal of rocuronium\u2010induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-4464","authenticated-orcid":false,"given":"Sang\u2010Hwan","family":"Ji","sequence":"first","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-9954","authenticated-orcid":false,"given":"Ki Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-8587","authenticated-orcid":false,"given":"Jaeseong","family":"Oh","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee\u2010Jeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-4104","authenticated-orcid":false,"given":"Young\u2010Eun","family":"Jang","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-1935","authenticated-orcid":false,"given":"Eun\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-8191","authenticated-orcid":false,"given":"Ji\u2010Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-0081","authenticated-orcid":false,"given":"Jin\u2010Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-7944","authenticated-orcid":false,"given":"Hee\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital  Seoul 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