{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:05:16Z","timestamp":1776215116792,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal of this study was to determine whether CYP2D6 metabolizer status within the ondansetron\u2010treated pediatric tonsillectomy population is associated with risk of postoperative nausea and vomiting (PONV) in the post\u2010anesthesia care unit. We conducted a retrospective cohort study of pediatric patients (&lt;18\u2009years) who underwent tonsillectomy and received ondansetron on the day of the procedure. Data were obtained from BioVU, an institutional biobank that links DNA to de\u2010identified electronic health record data. Subjects were tested for 10 <jats:italic>CYP2D6<\/jats:italic> allelic variants and copy number variation, and genotype data translated into CYP2D6 metabolizer status. The cohort included 652 individuals, 105 (16.1%) of whom had PONV. Rates of PONV were similar across groups: ultrarapid metabolizers (UMs), 1 of 9 (11.1%); normal metabolizers (NMs), 64 of 354 (18.1%); intermediate metabolizers (IMs), 33 of 234 (14.1%); poor metabolizers (PMs), 6 of 39 (15.4%); and ambiguous phenotypes, 1 of 16 (6.3%). In multivariable analysis adjusted for age, sex, and time under anesthesia, CYP2D6 metabolizer status was not associated with PONV, with an odds ratio of 1.37 (95% confidence interval 0.9, 2.1) when comparing PM\/IM versus NM\/UM. In this large pediatric population, no significant differences were detected for PONV based on CYP2D6 metabolizer status. Further investigation is needed to determine mechanisms for ondansetron inefficacy in children.<\/jats:p>","DOI":"10.1111\/cts.13447","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T15:59:36Z","timestamp":1668009576000},"page":"269-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pediatric <scp>CYP2D6<\/scp> metabolizer status and <scp>post\u2010tonsillectomy<\/scp> nausea and vomiting after ondansetron"],"prefix":"10.1111","volume":"16","author":[{"given":"Katherine","family":"Black","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. Randall","family":"Brenn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesia Shriner's Hospitals for Children\u2010Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-1893","authenticated-orcid":false,"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City and Department of Pediatrics University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Wanderer","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Biomedical Informatics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-1405","authenticated-orcid":false,"given":"Sara L.","family":"Van Driest","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, and the Center for Pediatric Precision Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm7040014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.29411"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2161"},{"key":"e_1_2_9_5_1","unstructured":"Gastrointestinal Motility and Water Flux Emesis and Biliary and Pancreatic Disease | Goodman & Gilman's: The Pharmacological Basis of Therapeutics 13\u2009e | AccessPharmacy | McGraw Hill Medical.https:\/\/accesspharmacy\u2010mhmedical\u2010com.proxy.library.vanderbilt.edu\/content.aspx?bookid=2189&sectionid=172483503#1162543032. 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