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A population PK model for oxypurinol was developed with NONMEM (version 7.3). The influence of urate transporter genetic variants for <jats:italic>ABCG2<\/jats:italic> (<jats:italic>rs2231142<\/jats:italic> and <jats:italic>rs10011796<\/jats:italic>), <jats:italic>SLC2A9\/GLUT9<\/jats:italic> (<jats:italic>rs11942223<\/jats:italic>), <jats:italic>SLC17A1\/NPT1<\/jats:italic> (<jats:italic>rs1183201<\/jats:italic>), <jats:italic>SLC22A12\/URAT1<\/jats:italic> (<jats:italic>rs3825018<\/jats:italic>), <jats:italic>SLC22A11\/OAT4<\/jats:italic> (<jats:italic>rs17300741<\/jats:italic>), and <jats:italic>ABCC4\/MRP4<\/jats:italic> (<jats:italic>rs4148500<\/jats:italic>), as well as other participant factors on oxypurinol PKs was assessed. Data from 325 people with gout were available. The presence of the T allele for <jats:italic>ABCG2<\/jats:italic> (<jats:italic>rs2231142<\/jats:italic>) and <jats:italic>SLC17A1<\/jats:italic>\/<jats:italic>NPT1<\/jats:italic> (<jats:italic>rs1183201<\/jats:italic>) was associated with a 24% and 22% increase in oxypurinol clearance, respectively, in univariate analysis. This effect was not significant in the multivariate analysis. In the final model, oxypurinol PKs were predicted by creatinine clearance, diuretic use, ethnicity, and body weight. We have found that genetic variability in the transporters examined does not appear to influence oxypurinol PKs.<\/jats:p>","DOI":"10.1111\/cts.13460","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T07:03:53Z","timestamp":1668755033000},"page":"422-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics"],"prefix":"10.1111","volume":"16","author":[{"given":"Hailemichael Z.","family":"Hishe","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Otago  Dunedin New Zealand"},{"name":"School of Pharmacy Mekelle University  Mekelle Tigray Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Sydney  New South Wales Sydney Australia"},{"name":"Department of Clinical Pharmacology &amp; Toxicology St. Vincent's Hospital Sydney  Darlinghurst New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-2912","authenticated-orcid":false,"given":"Lisa K.","family":"Stamp","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R.","family":"Merriman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Otago  Dunedin New Zealand"},{"name":"Division of Clinical Immunology and Rheumatology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Phipps\u2010Green","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-9252","authenticated-orcid":false,"given":"Daniel F. 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