{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:28:05Z","timestamp":1768811285441,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study tested the hypothesis that bowel preparation with mannitol should not affect the colonic concentration of H<jats:sub>2<\/jats:sub> and CH<jats:sub>4<\/jats:sub>. Therefore, the SATISFACTION study, an international, multicenter, randomized, parallel\u2010group phase II\u2013III study investigated this issue. The phase II dose\u2010finding part of the study evaluated H<jats:sub>2<\/jats:sub>, CH<jats:sub>4<\/jats:sub>, and O<jats:sub>2<\/jats:sub> concentrations in 179 patients randomized to treatment with 50\u2009g, 100\u2009g, or 150\u2009g mannitol. Phase III of the study compared the presence of intestinal gases in 680 patients randomized (1:1) to receive mannitol 100\u2009g in single dose or a standard split\u2010dose 2\u2009L polyethylene glycol (PEG)\u2010Asc preparation (2\u2009L PEG\u2010Asc). Phase II results showed that mannitol did not influence the concentration of intestinal gases. During phase III, no patient in either group had H<jats:sub>2<\/jats:sub> or CH<jats:sub>4<\/jats:sub> concentrations above the critical thresholds. In patients with H<jats:sub>2<\/jats:sub> and\/or CH<jats:sub>4<\/jats:sub> levels above detectable concentrations, the mean values were below the risk thresholds by at least one order of magnitude. The results also highlighted the effectiveness of standard washing and insufflation maneuvers in removing residual intestinal gases. In conclusion, bowel cleansing with mannitol was safe as the concentrations of H<jats:sub>2<\/jats:sub> and CH<jats:sub>4<\/jats:sub> were the same as those found in patients prepared with 2\u2009L PEG\u2010Asc. In both groups, the concentrations of gases were influenced more by the degree of cleansing achieved and the insufflation and washing maneuvers performed than by the preparation used for bowel cleansing. The trial protocol was registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04759885\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04759885<\/jats:ext-link>) and with EudraCT (eudract_number: 2019\u2010002856\u201018).<\/jats:p>","DOI":"10.1111\/cts.13486","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T11:28:53Z","timestamp":1676633333000},"page":"759-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors influencing the presence of potentially explosive gases during colonoscopy: Results of the <scp>SATISFACTION<\/scp> study"],"prefix":"10.1111","volume":"16","author":[{"given":"Marino","family":"Carnovali","sequence":"first","affiliation":[{"name":"Ospedale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Spada","sequence":"additional","affiliation":[{"name":"U.O. 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Endoscopia Digestiva Fondazione Poliambulanza \u2013 Istituto Ospedaliero  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Costamagna","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS  Rome Italy"},{"name":"Centre for Endoscopic Research Therapeutics and Training Universit\u00e0 Cattolica S. Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanai","family":"Di\u00a0Paolo","sequence":"additional","affiliation":[{"name":"U.O.C. 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