{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:36:00Z","timestamp":1790789760837,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NUT midline carcinoma family member 1 (<jats:italic>NUTM1<\/jats:italic>) fusions were originally identified in poorly differentiated and clinically aggressive carcinomas typically located in the midline structures of children and young adults, and collectively known as NUT (midline) carcinomas. Next\u2010generation sequencing later uncovered <jats:italic>NUTM1<\/jats:italic> fusions in a variety of other pediatric and adult cancers of diverse location and type, including hematologic malignancies, cutaneous adnexal tumors, and sarcomas. A vast array of <jats:italic>NUTM1<\/jats:italic> fusions with bromodomain containing 4 (<jats:italic>BRD4)<\/jats:italic> or bromodomain containing 3 (<jats:italic>BRD3)<\/jats:italic>, which are characteristic of NUT carcinoma, and with several other fusion partners have been identified and associated with variable prognosis. These non\u2010kinase fusions are thought to cause epigenetic reprogramming, thereby promoting proliferation, and hindering the differentiation of cancer cells. Many questions about both the function of the na\u00efve NUTM1 protein, which is mostly restricted to the germ cells of the testis and is related to spermatogenesis and the oncogenic mechanisms of the various <jats:italic>NUTM1<\/jats:italic> fusions in both adult and pediatric cancer, are still unanswered. Moreover, whether there is a relationship defined by the presence of <jats:italic>NUTM1<\/jats:italic> fusions between conventional NUT carcinoma and other <jats:italic>NUTM1<\/jats:italic>\u2010rearranged neoplasms remains to be elucidated. This review will focus on recent discoveries of <jats:italic>NUTM1<\/jats:italic> fusions found in pediatric cancers, their prognostic impact, and emergence as novel oncogenic drivers.<\/jats:p>","DOI":"10.1111\/cts.13535","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:20:13Z","timestamp":1682058013000},"page":"1331-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The expanding universe of <scp><i>NUTM1<\/i><\/scp> fusions in pediatric cancer"],"prefix":"10.1111","volume":"16","author":[{"given":"Rosane","family":"Charlab","sequence":"first","affiliation":[{"name":"Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Racz","sequence":"additional","affiliation":[{"name":"Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092234"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.860830"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28060381"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22838"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01333-y"},{"key":"e_1_2_11_7_1","unstructured":"U.S Food and Drug Administration.Oncology Center of Excellence Pediatric Oncology.https:\/\/www.fda.gov\/about\u2010fda\/oncology\u2010center\u2010excellence\/pediatric\u2010oncology. 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