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The objective of this study was to assess secukinumab's efficacy, treatment patterns, and characteristics in patients with moderate\u2010to\u2010severe plaque psoriasis. This 24\u2010week, multicenter (<jats:italic>n<\/jats:italic>\u2009=\u20095) retrospective study analyzed the data of Chinese adult patients with moderate\u2010to\u2010severe plaque psoriasis who initiated secukinumab treatment between May 2019 and March 2020. The Psoriasis Area and Severity Index (PASI), body surface area (BSA), Investigator's Global Assessment Modified 2011 (IGA mod 2011), and Dermatology Life Quality Index (DLQI) were assessed. Dermatologists documented the treatment dosage and modification reasons. Of the 244 secukinumab\u2010na\u00efve patients, most were men (73.4%, 179\/244) and weighed 60\u201390\u2009kg (72.8%, 177\/243). The mean (SD) age at secukinumab initiation was 38.1 (11.6) years, and the disease duration was 13.5 (7.9) years. Most patients (97.1%, 237\/244) received secukinumab 300\u2009mg. At weeks 4, 12, 16, and 24, the proportion of patients achieving PASI 75 (\u226575% reduction from baseline) was 40.0%, 92.1%, 88.4%, and 88.9%, respectively; PASI 90 was 15.0%, 73.7%, 81.4%, and 68.3%, respectively; and PASI 100 was 8.7%, 40.8%, 58.1%, and 41.3%, respectively. During the same periods, BSA and IGA mod 2011 showed similar improvement trends. An increasing proportion of patients achieved DLQI of 0\u20131 (21.6%, 65.7%, 75.0%, and 80.3%, respectively). Treatment modification was highest at week 12. The average interval between two administrations after week 4 was 62.95\u2009days. Secukinumab was highly effective in improving the PASI, IGA, BSA, and DLQI in Chinese patients with moderate\u2010to\u2010severe plaque psoriasis throughout the first 24\u2009weeks. The treatment pattern for Chinese patients differs from that in the clinical guidelines.<\/jats:p>","DOI":"10.1111\/cts.13583","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:39:15Z","timestamp":1693377555000},"page":"1803-1814","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment outcomes of secukinumab in adult patients with <scp>moderate\u2010to\u2010severe<\/scp> plaque psoriasis in China: A real\u2010world multicenter retrospective study"],"prefix":"10.1111","volume":"16","author":[{"given":"Yangfeng","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Skin Disease Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Rare Disease Center West China Hospital of Sichuan University  37# Guoxue Alley, Wuhou District Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People's Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dalian Dermatology Hospital  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaojie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Rare Disease Center West China Hospital of Sichuan University  37# Guoxue Alley, Wuhou District Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Dermatology Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Novartis Pharma Co., Ltd.  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