{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:09:22Z","timestamp":1773745762037,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD), newly renamed metabolic dysfunction\u2010associated liver disease (MASLD), is a leading cause of liver disease in children and adults. There is a paucity of data surrounding potential biomarkers and therapeutic targets, especially in pediatric NAFLD. Leukocyte cell\u2010derived chemotaxin 2 (LECT2) is a chemokine associated with both liver disease and skeletal muscle insulin resistance. Our aim was to determine associations between LECT2 and common clinical findings of NAFLD in pediatric patients. Enzyme\u2010linked immunosorbent assay (ELISA) was used to measure serum LECT2 concentrations in children (aged 2\u201317\u2009years) with and without NAFLD. LECT2 concentrations were then correlated to clinical parameters in NAFLD. Mean LECT2 was significantly elevated in children with NAFLD versus healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200963 vs. 42, 5.83\u2009\u00b1\u20091.98 vs. 4.02\u2009\u00b1\u20092.02\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). Additionally, LECT2 had strong correlations with body mass index (BMI) (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.301, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). A LECT2 concentration of 3.76\u2009mg\/mL predicts NAFLD with a sensitivity of 90.5% and specificity of 54.8%. Principal component analysis and logistic regression models further confirmed associations between LECT2 and NAFLD status. This study demonstrates increased serum LECT2 concentrations in pediatric NAFLD, which correlates with BMI and shows strong predictive value within these patients. Our data indicate that LECT2 is a potential diagnostic biomarker of disease and should be further investigated in pediatric as well as adult NAFLD.<\/jats:p>","DOI":"10.1111\/cts.13666","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T10:13:48Z","timestamp":1698228828000},"page":"2719-2728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leukocyte cell\u2010derived chemotaxin 2 correlates with pediatric non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-9497","authenticated-orcid":false,"given":"Diego","family":"Paine\u2010Cabrera","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa K.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Mercy \u2013 Kansas City  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dakota R.","family":"Robarts","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-0685","authenticated-orcid":false,"given":"Michele T.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"University of Kansas Liver Center  Kansas City Kansas 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