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This study focuses on the G2019S missense mutation in the <jats:italic>LRRK2<\/jats:italic> gene, which is associated with hereditary and sporadic PD. Utilizing data from the PPMI database, we conducted an analysis of baseline clinical characteristics, as well as serum and cerebrospinal fluid levels in two groups: patients with PD with the G2019S mutation (PD\u2009+\u2009G2019S) and patients with PD without the mutation (PD\u2010G2019S). Multiple linear regression and longitudinal analysis were performed, controlling for confounding factors. Compared to the PD\u2010G2019S group, the PD\u2009+\u2009G2019S group showed more obvious initial motor dysfunction\u2014higher baseline Movement Disorder Society\u2010Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS\u2010UPDRS) scores (false discovery rate [FDR]\u2010adjusted <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but progressed more slowly. Mechanism of Coordinated Access and activities of daily living (ADL) scores were lower at baseline (FDR\u2010adjusted <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas Scales for Outcomes of Parkinson's Disease (SCOPA)\u2010Thermoregulatory (FDR\u2010adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.015) scores were higher, emphasizing the increase of non\u2010motor symptoms associated with LRRK2\u2010G2019S mutation. During the follow\u2010up period, the motor and non\u2010motor symptoms changed dynamically with time, and there were longitudinal differences in the scores of MDS\u2010UPDRS (FDR\u2010adjusted <jats:italic>P<\/jats:italic><jats:sub>I<\/jats:sub>\u2009=\u20090.013, <jats:italic>P<\/jats:italic><jats:sub>II<\/jats:sub>\u2009=\u20090.008, <jats:italic>P<\/jats:italic><jats:sub>IV<\/jats:sub>\u2009&lt;\u20090.001), Questionnaire for Impulsive\u2010Compulsive Disorders in Parkinson's Disease (FDR\u2010adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.027), SCOPA\u2010Thermoregulatory (FDR\u2010adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.021), and ADL (FDR\u2010adjusted <jats:italic>p<\/jats:italic>\u2009=\u20090.027) scale scores. PD associated with the LRRK2 G2019S mutation demonstrated more severe symptoms at baseline but slower progression. Motor complications and thermoregulatory disorders were more pronounced.<\/jats:p>","DOI":"10.1111\/cts.13720","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T13:41:08Z","timestamp":1706017268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the <scp>LRRK2 G2019S<\/scp> mutation: Data from the <scp>PPMI<\/scp> study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-8375","authenticated-orcid":false,"given":"Xiaohui","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Qingdao University  Qingdao 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