{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:56Z","timestamp":1753878416481,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to investigate the differential expression of insulin\u2010like growth factor 2 mRNA\u2010binding protein 3 (IGF2BP3) in the peritoneal dialysate among patients with different durations of peritoneal dialysis and its association with the angiogenic marker vascular* endothelial growth factor (VEGF), the fibronectin (FN), and various clinical indicators. A cohort of 122 peritoneal dialysis patients was categorized into short\u2010term (\u22641\u2009year, <jats:italic>n<\/jats:italic>\u2009=\u200933), mid\u2010term (&gt;1 and \u22645\u2009years, <jats:italic>n<\/jats:italic>\u2009=\u200955), and long\u2010term (&gt;5\u2009years, <jats:italic>n<\/jats:italic>\u2009=\u200934) groups based on dialysis duration. We utilized enzyme\u2010linked immunosorbent assay (ELISA) and western blot assays to quantify the levels of IGF2BP3, VEGF, and FN in the dialysate. Our findings showed a progressive increase in IGF2BP3 levels with the duration of PD, with the long\u2010term group exhibiting significantly higher levels than both the short\u2010term and mid\u2010term groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A positive correlation between IGF2BP3 and VEGF (<jats:italic>r<\/jats:italic>\u2009=\u20090.386, <jats:italic>p<\/jats:italic>\u2009=\u20090.013), as well as between IGF2BP3 and FN (<jats:italic>r<\/jats:italic>\u2009=\u20090.340, <jats:italic>p<\/jats:italic>\u2009=\u20090.030), was observed. IGF2BP3 levels also correlated positively with serum creatinine, calcium, and phosphorus levels. In\u00a0vitro analysis further confirmed that IGF2BP3 expression is enhanced in human peritoneal mesothelial cells under high\u2010glucose conditions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The study highlights the potential of IGF2BP3 in PD effluent as a biomarker for monitoring PF progression, with its expression significantly correlated with the duration of PD (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.897, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, our results underscore a correlation between elevated IGF2BP3 levels and PD duration, suggesting the clinical significance of IGF2BP3 as a biomarker for PF progression.<\/jats:p>","DOI":"10.1111\/cts.13774","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T04:44:40Z","timestamp":1712033080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential expression and clinical significance of <scp>IGF2BP3<\/scp> in peritoneal dialysate of patients with varying duration of peritoneal dialysis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1479-8710","authenticated-orcid":false,"given":"Xiaoqi","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Nephropathy The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0944-7046","authenticated-orcid":false,"given":"Ling","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Nephropathy The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1523-3208","authenticated-orcid":false,"given":"Jiao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephropathy The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2828-4621","authenticated-orcid":false,"given":"Mengmeng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephropathy The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-2270","authenticated-orcid":false,"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephropathy The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3543678"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109778"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.130"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.02.050"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00302-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.8.575"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00363"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.545"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060476"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.711207"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01570"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01714-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.162060"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491987"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094831"},{"key":"e_1_2_12_17_1","first-page":"927","article-title":"Stan 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