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In another aspect, this study was focused on the anti\u2010OB efficacy of the non\u2010fatty acids (NFAs) in PAF through network pharmacology (NP). Natural product activity &amp; species source (NPASS), SwissADME, similarity ensemble approach (SEA), Swiss target prediction (STP), DisGeNET, and online Mendelian inheritance in man (OMIM) were utilized to gather significant molecules and its targets. The crucial targets were adopted to construct certain networks: protein\u2013protein interaction (PPI), PAF\u2010signaling pathways\u2010targets\u2010compounds (PSTC) networks, a bubble chart, molecular docking assay (MDA), and density function theory (DFT). Finally, the toxicities of the key compounds were validated by ADMETlab 2.0 platform. All 41 compounds in PAF conformed to Lipinski's rule, and the key 31 targets were identified between OB and PAF. On the bubble chart, PPAR signaling pathway had the highest rich factor, suggesting that the pathway might be an agonism for anti\u2010OB. Conversely, estrogen signaling pathway had the lowest rich factor, indicating that the mechanism might be antagonism against OB. Likewise, the PSTC network represented that AKT1 had the greatest degree value. The MDA results showed that AKT1\u2010gamma\u2010tocopherol, PPARA\u2010fucosterol, PPARD\u2010stigmasterol, (PPARG)\u2010fucosterol, (NR1H3)\u2010campesterol, and ILK\u2010alpha\u2010tocopherol formed the most stable conformers. The DFT represented that the five molecules might be promising agents via multicomponent targeting. Overall, this study suggests that the NFAs in PAF might play important roles against OB.<\/jats:p>","DOI":"10.1111\/cts.13778","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T07:20:23Z","timestamp":1711092023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New insight of chemical constituents in <i>Persea americana<\/i> fruit against obesity via integrated pharmacology"],"prefix":"10.1111","volume":"17","author":[{"given":"Min\u2010Gi","family":"Cha","sequence":"first","affiliation":[{"name":"Institute for Liver and Digestive Diseases, College of Medicine, Hallym University  Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Been","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases, College of Medicine, Hallym University  Chuncheon 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