{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:54:32Z","timestamp":1778889272482,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sleep deprivation is a prevalent problem in critically ill patients, which leads to delayed recovery and delirium. Slow\u2010wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically ill patients. We performed a prospective open\u2010label randomized controlled study to compare SWS and the clinical outcomes of gabapentin versus a control intervention in critically ill adult patients admitted to the intensive care unit (ICU) within 24\u2009h. The patients' characteristics and sleep\u2010related outcomes were recorded. The sleep\u2010related outcomes, namely, bispectral analysis (BIS), the Richards\u2010Campbell Sleep Questionnaire (RCSQ), and insulin\u2010like growth factor\u20101 (IGF\u20101) levels, were evaluated. Furthermore, clinical outcomes and safety were assessed. Sixty patients from 348 cases were eligible for randomization. On day 3 of the study, patients in the gabapentin group had significantly increased SWS (66.79 vs. 0.00\u2009min; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), total sleep time (TST) (331.39 vs. 46.16\u2009min; <jats:italic>p<\/jats:italic>\u2009=\u20090.001), RCSQ score (55.05\u2009\u00b1\u200920.18 vs. 32.80\u2009\u00b1\u200915.31; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and IGF\u20101 concentrations (84.33\u2009\u00b1\u200912.40 vs. 44.00\u2009\u00b1\u200910.20\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with the control group. Improvements in clinical outcomes, such as delirium, ICU\u2010free days, and mechanical ventilator\u2010free days, were observed; however, these differences did not reach statistically significant. Gabapentin at bedtime increased SWS, TST, and IGF\u20101 concentrations in critically ill patients. This regimen might be beneficial to critically ill patients for improving their sleep quality.<\/jats:p>","DOI":"10.1111\/cts.13815","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T04:40:08Z","timestamp":1716871208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of gabapentin on slow\u2010wave sleep period in critically ill adult patients: A randomized controlled trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-6621","authenticated-orcid":false,"given":"Kanyarat","family":"Susantitapong","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"},{"name":"Pharmacy Unit King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-9951","authenticated-orcid":false,"given":"Pitchaya","family":"Dilokpattanamongkol","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-0962","authenticated-orcid":false,"given":"Yuda","family":"Sutherasan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-4444","authenticated-orcid":false,"given":"Somprasong","family":"Liamsombut","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuthamanee","family":"Suthisisang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02728-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003299"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1397-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610394322"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874828701306010080"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.101223"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.06.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.54.5.311"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0043-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1142-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6871"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709334"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.56"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2016.1202764"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.02.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20693"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2374373519882234"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"811","article-title":"Sleep neurobiology for the clinician","volume":"27","author":"Espa\u00f1a RA","year":"2004","journal-title":"Sleep"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5.2S.S4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5966"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181cda242"},{"key":"e_1_2_10_24_1","volume-title":"StatPearls","author":"Hanson JA","year":"2022"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.5.707"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30450-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0427"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.027"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2016.05.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463720912496"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.10.005"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v03n0303"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-202"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26345"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.12.011"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-825"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014381"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0110"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185561"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101017"},{"key":"e_1_2_10_42_1","article-title":"Respiratory pathophysiology: sleep\u2010related breathing disorders. GMS Curr top Otorhinolaryngol","volume":"5","author":"Sch\u00e4fer T","year":"2006","journal-title":"Head Neck Surg"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10117"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0399-8"},{"key":"e_1_2_10_45_1","volume-title":"Infection Prevention and Control During Health Care When Coronavirus Disease (COVID\u201019) Is Suspected or Confirmed: Interim Guidance, 12 July 2021","author":"World Health Organization","year":"2021"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154102"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1891\/1061-3749.8.2.131"},{"issue":"22","key":"e_1_2_10_48_1","first-page":"62","article-title":"Effects of nonpharmacological interventions on sleep improvement and delirium prevention in critically ill patients: a systematic review and meta\u2010analysis","volume":"16","author":"Kang J","year":"2022","journal-title":"Aust Crit Care"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T11:25:40Z","timestamp":1716895540000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cts.13815"],"URL":"https:\/\/doi.org\/10.1111\/cts.13815","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2024-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13815"}}