{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:07:23Z","timestamp":1789225643675,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bloodstream infections (BSI) caused by carbapenem\u2010resistant Enterobacterales (CRE) are associated with a high mortality rate. This study aimed to investigate factors associated with 14\u2010day mortality and identify a potential treatment option. A retrospective cohort study was conducted on patients with CRE\u2010BSI in Thailand from 2015 to 2020. The multivariate Cox proportional\u2010hazards model was employed to identify factors influencing 14\u2010day mortality. Out of 134 diagnosed cases of CRE\u2010BSI, the all\u2010cause 14\u2010day mortality rate was 35.1%. The most prevalent organism isolated was\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (85.8%), followed by\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (11.9%). Among the 60 isolates tested for carbapenemase genes, the majority exhibited co\u2010occurring\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20101<\/jats:sub>\n                    and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA\u201048<\/jats:sub>\n                    (51.7%), followed by\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA\u201048<\/jats:sub>\n                    (31.7%) and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20101<\/jats:sub>\n                    (15.0%). In the multivariate analysis, neutropenia (adjusted hazard ratio [aHR] 2.55; 95% confidence interval [95%CI] 1.28\u20135.06;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), sepsis\/septic shock (aHR 3.02; 95%CI 1.33\u20136.86;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), and previous metronidazole exposures (aHR 3.58; 95%CI 1.89\u20136.71;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were identified as independent factors for 14\u2010day mortality. The fosfomycin\u2010based regimen was found to be protective (aHR 0.37; 95%CI 0.15\u20130.92;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032). In patients with CRE\u2010BSI, particularly in regions with a high occurrence of co\u2010occurring\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20101<\/jats:sub>\n                    and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA\u201048<\/jats:sub>\n                    , neutropenia, sepsis\/septic shock, and previous metronidazole exposures emerged as independent risk factors for mortality. Moreover, the fosfomycin\u2010based regimen showed an improvement in the survival rate.\n                  <\/jats:p>","DOI":"10.1111\/cts.13855","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:49:14Z","timestamp":1717980554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mortality factors and antibiotic options in carbapenem\u2010resistant Enterobacterales bloodstream infections: Insights from a high\u2010prevalence setting with co\u2010occurring\n                    <scp>NDM<\/scp>\n                    \u20101 and\n                    <scp>OXA<\/scp>\n                    \u201048"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6482-0747","authenticated-orcid":false,"given":"Palat","family":"Karnmueng","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacy, Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"},{"name":"Department of Pharmacy Practice, College of Pharmacy Rangsit University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-2939","authenticated-orcid":false,"given":"Preecha","family":"Montakantikul","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6193-6433","authenticated-orcid":false,"given":"Taniya","family":"Paiboonvong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Rangsit University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-1209","authenticated-orcid":false,"given":"Rongpong","family":"Plongla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Thai Red Cross Society  Bangkok Thailand"},{"name":"Center of Excellence in Antimicrobial Resistance and Stewardship Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-1167","authenticated-orcid":false,"given":"Tanittha","family":"Chatsuwan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Antimicrobial Resistance and Stewardship Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Microbiology, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-2249","authenticated-orcid":false,"given":"Supatat","family":"Chumnumwat","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Department of Pharmacy, Faculty of Pharmacy Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.WHO publishes list of bacteria for which new antibiotics are urgently needed. Accessed November 26 2023.https:\/\/www.who.int\/news\u2010room\/detail\/27\u201002\u20102017\u2010who\u2010publishes\u2010list\u2010of\u2010bacteria\u2010for\u2010which\u2010new\u2010antibiotics\u2010are\u2010urgently\u2010needed"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30210-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051121"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106554"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.04.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00080"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-021-00950-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0080"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S321147"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030355"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad046"},{"key":"e_1_2_10_16_1","unstructured":"Centers for Disease Control and Prevention.Facility guidance for control of carbapenem\u2010resistant Enterobacteriaceae (CRE). November 2015 update \u2013 CRE toolkit.https:\/\/www.cdc.gov\/hai\/organisms\/cre\/cre\u2010toolkit\/index.html"},{"key":"e_1_2_10_17_1","unstructured":"PAW.Clinical and laboratory standards institute: performance standards for antimicrobial susceptibility testing: 30th informational supplement. CLSI Document M100\u2010S20.2020."},{"key":"e_1_2_10_18_1","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST).Clinical breakpoints \u2013 breakpoints and guidance. Accessed August 30 2020.https:\/\/eucast.org\/clinical_breakpoints\/"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.12.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl481"},{"key":"e_1_2_10_21_1","unstructured":"NCI Dictionary of Cancer Terms [Internet].National Cancer Institute. [cited 2020 Jun 16].https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer\u2010terms\/def\/immunocompromised"},{"key":"e_1_2_10_22_1","unstructured":"National Center for Emerging and Zoonotic Infectious Diseases [Internet].Centers for Disease Control and Prevention. [cited 2020 Jun 21].https:\/\/www.cdc.gov\/parasites\/crypto\/gen_info\/infect_ic.html"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.019"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30792-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.972900"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.08.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3961684"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12563"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13949"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2020.52.4.516"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4046"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2022.0098"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03099-15"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.03.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9090615"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.07.014"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2023.01.005"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.13855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T22:15:37Z","timestamp":1719958537000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.13855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/cts.13855"],"URL":"https:\/\/doi.org\/10.1111\/cts.13855","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13855"}}