{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:34Z","timestamp":1753878034972,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some anti\u2010mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life\u2010threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE\u2010PEOPLE trial evaluating the safety of bedaquiline\u2010enhanced post\u2010exposure prophylaxis (bedaquiline and rifampicin, BE\u2010PEP, versus rifampicin, SDR\u2010PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post\u2010exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L\u2010ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L\u2010ECG and mECG were 394\u2009\u00b1\u200919 and 385\u2009\u00b1\u200918\u2009ms, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a strong correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.793). The mean absolute QTc difference between both modalities was 11\u2009\u00b1\u200910\u2009ms. Mean manual and automated 12L\u2010ECG QTc were 394\u2009\u00b1\u200919 and 409\u2009\u00b1\u200919\u2009ms, respectively (<jats:italic>n<\/jats:italic>\u2009=\u2009636; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), corresponding to moderate agreement (<jats:italic>r<\/jats:italic>\u2009=\u20090.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8\u2009ms. Automated QTc measurements were less accurate, yielding longer QTc intervals.<\/jats:p>","DOI":"10.1111\/cts.13861","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T06:14:07Z","timestamp":1722320047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline\u2010enhanced prophylactic leprosy treatment"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-9105","authenticated-orcid":false,"given":"Auke T.","family":"Bergeman","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart Centre, Amsterdam UMC location AMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Nourdine","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Piubello","sequence":"additional","affiliation":[{"name":"Damien Foundation  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahara","family":"Salim","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-8257","authenticated-orcid":false,"given":"Sofie M.","family":"Braet","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"Baco","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silahi H.","family":"Grillone","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rian","family":"Snijders","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolien","family":"Hoof","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achilleas","family":"Tsoumanis","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4448-0526","authenticated-orcid":false,"given":"Harry","family":"van Loen","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younoussa","family":"Assoumani","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboubacar","family":"Mzembaba","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Control Program  Moroni Comoros"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimer","family":"Ortu\u00f1o\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Damien Foundation  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Epco","family":"Hasker","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-8527","authenticated-orcid":false,"given":"Christian","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Centre, Amsterdam UMC location AMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1017-4675","authenticated-orcid":false,"given":"Bouke C.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8652062"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30396-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39500.885752.BE"},{"volume-title":"Guidelines for the Diagnosis, Treatment and Prevention of Leprosy","year":"2018","author":"World Health Organization. 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