{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:05:05Z","timestamp":1783127105957,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This cohort study aims to assess the connection between cytochrome P450 family 2 subfamily C member 19 (CYP2C19) genotyping, platelet aggregability following oral clopidogrel administration, and the occurrence of postoperative atrial fibrillation (POAF) after off\u2010pump coronary artery bypass graft (CABG) surgery. From May 2017 to November 2022, a total of 258 patients undergoing elective first\u2010time CABG surgery, receiving 100\u2009mg\/day oral aspirin and 75\u2009mg\/day oral clopidogrel postoperatively, was included for analysis. These patients were categorized based on CYP2C19 genotyping. Platelet aggregability was assessed serially using multiple\u2010electrode aggregometry before CABG, 1 and 5\u2009days after the procedure, and before discharge. The incidences of POAF were compared using the log\u2010rank test for cumulative risk. CYP2C19 genotyping led to categorization into CYP2C19*1*1 (WT group, <jats:italic>n<\/jats:italic>\u2009=\u2009123) and CYP2C19*2 or *3 (LOF group, <jats:italic>n<\/jats:italic>\u2009=\u2009135). Baseline characteristics and operative data showed no significant differences between the two groups. The incidence of POAF after CABG was 42.2% in the LOF group, contrasting with 22.8% in the WT group (hazard risk [HR]: 2.061; 95% confidence interval [CI]: 1.347, 3.153; <jats:italic>p<\/jats:italic>\u2009=\u20090.0013). Adenosine diphosphate\u2010stimulated platelet aggregation was notably higher in the LOF group compared to the WT group 5\u2009days after CABG (30.4%\u2009\u00b1\u20096.5% vs. 17.9%\u2009\u00b1\u20094.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), remaining a similar higher level at hospital discharge (25.6%\u2009\u00b1\u20096.1% vs. 12.2%\u2009\u00b1\u20093.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The presence of CYP2C19 LOF was linked to a higher incidence of POAF and relatively elevated platelet aggregation after CABG surgery under the same oral clopidogrel regimen.<\/jats:p>","DOI":"10.1111\/cts.13862","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T05:15:28Z","timestamp":1718428528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of <scp>CYP2C19<\/scp> genotypes with postoperative atrial fibrillation after coronary artery bypass surgery"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-359X","authenticated-orcid":false,"given":"Qin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Sichuan Provincial People's Hospital Affiliated Hospital of University of Electronic Science and Technology  Chengdu 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